High Intensity Health with Mike Mutzel, MS

Alzheimer’s disease and dementia prevalence and deaths are on the rise, claiming over 6,000 lives in the USA every week! Yet many people don’t even know their APOE genotype, which arguably has the biggest impact on future Alzheimer’s disease and dementia as well as cardiovascular disease risk.

In this show we dive deeper into what the APOE gene does and how knowing this info can help tweak your nutrition and lifestyle helping to reduce risk of future disease—especially if you have one or two copies of the APOE ε4 gene.


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Time Stamps:

0:00 Intro
00:53 APOE is a gene that makes proteins that are involved in lipid binding.
01:10 APOE and Immunity
01:39 APOE 4 alleles and Alzheimer’s disease risk
03:13 3 different APOE isoforms: APOE2, APOE3, APOE4 allele.
03:44 Having the gene does not mean that you will get the disease.
04:35 APOE is involved in lipid metabolism
05:30 Lipoproteins and lipids transport
06:05 APOE can redistribute lipids across tissues and cell types.
07:40 APOE is secreted by the liver with VLDL and bile acids
08:00 Lipoprotein lipase facilitates your metabolic deposits. Hormone sensitive lipase facilitates your metabolic withdrawals.
09:42 Your omega 3 index and APE 4 isoform.
11:35 APOE4 and cholesterol
11:45 ApoB VS ApoE
12:09 APOE2 carriers tend to have a less atherogenic lipid profile.
12:15 APOE4 carriers are associated with decreased levels of APOE triglycerides and increased levels of APOB in lipoproteins
13:12 APOE4 puts genotype carriers at increased risk for heart disease. This is likely due to the association with APOE4 and elevated LDL and Apolipoprotein B.
14:07 APOE4 primes your microglia to be more inflammatory. Microglia are brain immune cells. They are involved in synaptic processing, pruning of cells, shaping neurons, and removing inflammatory debris. APOE4 carriers have decreased cerebral glucose metabolism and increased levels of beta amyloid and tau protein.
15:50 With APOE4, there are changes and increase of tau protein within the neurons. There are also alterations in the blood brain barrier integrity.
16:00 To preserve the integrity of the brain, moderate alcohol consumption, increase exercise, incorporate sauna therapy and sauna bathing, as it effects cerebral blood flow.
16:45 APOE is expressed in astrocytes, microglia and other vascular cells within the brain. Blood brain barrier prevents toxins and metabolic waste from going into your brain. Increased expression of APOE is detected in stressed neurons.
17:42 APOE isoforms affect lipid transport, glucose metabolism, mitochondrial function, synaptic plasticity, beta amyloid protein expression, tau protein and cerebral vascular function within the brain.
18:18 Ratio of APOE4 allele correlates with loss of gray matter volume and abnormal glucose metabolism, a hallmark of Alzheimer’s and dementia.
19:00 APOE4 is the greatest genetic risk factor for late onset Alzheimer’s disease. It also influences the risk and outcomes for stroke, MS, Parkinson’s disease, and frontotemporal dementia.
22:11 A low carb diet, high in wild caught fish, is protective for APOE4 carriers. It impacts brain metabolism and lipid levels favorably. Drive your glycemic load down.
24:05 If you are over the age of 50 and have one or two copies of the APOE4 allele, consider microdosing with rapamycin. Rapamycin is an mTOR inhibitor. It may delay the onset of Alzheimer’s and dementia.

Direct download: APOE_Deep_Dive.mp3
Category:general -- posted at: 11:49am PDT

Overeating, especially at night, can lead to fat and weight gain. We review some practical tips to help prevent the over-consumption of food and special considerations during the holiday season.

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Direct download: 4_Strategies_to_Prevent_Overeating__Especially_at_Night.mp3
Category:general -- posted at: 8:13am PDT

Standard lipid panels are actually mathematical approximations. Emerging data suggests using the very affordable ApoB to ApoA1 ratio more accurately assess cardiometabolic disease risk.


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Time Stamps

0:45 ApoB why it’s more accurate

1:30 High LDL on a ketogenic diet

2:24 Heart disease deaths increase in the winter

2:59 High LDL after fasted exercise

4:50 What ApoB means and why it matters

7:15 Why Omega-6 seed oils are bad if your LDL is high

9:11 Request your ApoB to A1 ratio instead

9:38 Standard cholesterol tests are a mathematical estimate

12:06: HDL and ApoA-1, how it’s cardioprotective

12:45 Harvard case study of LDL increases on a Keto diet

19:25 Advanced lipoprotein particle testing overview

Direct download: High_Cholesterol_Tests_Are_Inaccurate_Use_this_ApoB___ApoA1_Instead.mp3
Category:general -- posted at: 9:23am PDT

Assuming you've recently ordered the expanded labs that we suggested on page one of the Blood Work Cheat Sheet, here's a additional assessments to consider to see if your lifestyle is maximizing your health.

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Time Stamps

00:25 Measuring your omega 3 index is more important for men and post-menopausal women. Hormone changes in post-menopausal women greatly increases risk of heart disease.
0:44 Bill Harris, PhD explains the omega-3 index
2:23 An omega 3 index below 4%, reflects higher risk of sudden cardiac death, having a fatal heart attack, should they have a heart attack.
03:40 Omega 3s in the 6% to 8% range is optimal for reducing risk of sudden cardiac death, compared to those of us with omega 3 index of 3 or 4%.
04:00 OmegaQuant offers an at home test of your Omega 3s. The OmegaQuant test quantifies the percentage of EPA and DHA in your red blood cell membranes. They also look at palmitate.
04:15 When palmitate increases, it is a proxy that potentially de novo lipogenesis is occurring. This means that insulin is causing your liver to increase fatty acid synthesis, which can result in insulin resistance and fat gain.
05:15 A DEXA scan will show you where your fat is being distributed. It will also give insights into your bone mineral density. Ageing and gaining fat around the middle, has been linked with low mineral density and muscle mass.
05:23 Osteosarcopenic obesity is the simultaneous loss of bone mineral density, loss of muscle and gain of fat.
03:50 A DEXA scan every 2 years tracks the trajectory of your body composition and your muscle. The amount of fat on your body is a reflection of your vitality.
05:25 A full body MRI every 5 years or so can be done if you have cancer in your close family or you are a former smoker.
06:42 If cardiovascular disease runs in your family, or you have sleep apnea, iron overload or insulin resistance, you may consider testing your CIMT (carotid intimal thickness). It shows how much atherosclerosis or stenosis is in the carotid arteries. A coronary artery calcium score is more invasive.
07:30 The arterial pulse wave velocity test is non-invasive. It measures the elasticity of your vessels. Stiff arteries are characteristic of inflammation.

Direct download: Expanded_Labs_2022.mp3
Category:general -- posted at: 2:05pm PDT

Let's review some of the most resent Excess Death figures for 2021 and compare and contrast states like Florida to California and more. We also discuss on the first in vitro studies finding new mechanistic evidence that Omicron is indeed more mild than previous variants.

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Time Stamps:

0:20 New hints omicron will be mild
6:19 Excess Deaths
9:40 California VS Florida
11:08: Indirect effects of social isolation, being sedentary and more
17:28 Consequences of lockdowns and isolation
19:13 Recidivism in weight gain

Direct download: Excess_Deaths__in_2021_Review_.mp3
Category:general -- posted at: 12:00pm PDT

Exercise is arguably one of the fastest ways to decrease blood sugar and insulin as well as prime the body to burn more fat. We review a recent paper that discusses the history and new research about exercise as a glucose and insulin lowering tool.

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Time Stamps:


0:00 Intro
0:05 Insulin resistance is the root cause of many of today’s premature deaths and chronic disease expression.
0:32 Moving/exercising, especially in the post meal window, makes changes that decrease glucose levels and make your skeletal muscle more sensitive to the effects of insulin. This leads to reduced insulin output by your pancreas.
1:40 Insulin is involved in post meal processing and anabolic reaction. It helps build. It helps replenish depleted glycogen. It helps, in the post exercise window, to increase amino acid biosynthesis.
1:58 Exercise is favorable, but it is catabolic, meaning that it tears down.
2:23 Post meal glycemic levels flatten with exercise. Diabetics tend to use less insulin on days when they exercise and blood sugar levels decrease more quickly.
4:48 During exercise your muscles become a glucose sponge; muscle glucose uptake increases in an intensity and duration dependent manner. Glucose is needed to make ATP in your muscles.
5:40 Exercise increases the expression and sensitivity of GLUT4 transporter. GLUT4 can be desensitized by persistent elevation of glucose levels.
9:35 Insulin is a potent inhibitor of adipose tissue lipolysis, the ability of your fat cells to release stored lipids.
10:10 Pre-workout or intra-workout carbohydrates may slow down your fat lipolysis, or fat burning. If fat loss is your goal, you may want to consider exercising in a fasted state.
11:30 When you exercise, your adrenal glands release adrenaline and noradrenaline. These enhance the liberation of stored fat from your fat cells to use for cellular energy when you exercise.
11:50 Fasting and exercise both elevate adrenals. Prolonged fasting and overexercising can be hard on your adrenals.
12:40 High insulin reduces the normally a progressive rise in free fatty acid oxidation during exercise.
13:15 One Legged Study: The exercised leg increased its muscle glycogen stores to levels twice that of the sedentary leg. Exercise increases the ability of your moving muscles to store glycogen.
13:50 When you move your muscles, you are depleting glycogen with the muscle. Exercise helps your muscles become more insulin sensitive by depleting glycogen within the muscle, causing muscles to be more insulin sensitive in the post exercise window. A glycogen-depleting workout is a good way to kickoff your fast.
15:25 After dinner starts your overnight fast. Perhaps you could take a brisk walk or lift weights before dinner to blunt the post meal glycemic index level.
15:50 Doing your post meal exercise when your post meal blood glucose level peaks, has the best ability to reduce glucose levels. This peak is most often 45 to 60 minutes after a meal.
16:23 Eat early. Sleep early. Eat your carbs commensurate with your physical activity level. Go for a walk after your meal.
17:15 Insulin sensitivity can be boosted for up to 48 hours after a single exercise session. Exercise increases the transport of glucose from the bloodstream into muscles by a factor of 34.
18:45 Eccentric exercise, slow descent, muscle damaging effects can cause a transient reduction in insulin sensitivity. Moderation is key.
19:40 You are most insulin sensitive in the morning. You become more insulin resistant as the day progresses. Exercise when you can. Afternoon resistance training can blunt your dinner glycemic index.
20:45 Sprinkle exercise throughout the day. Researchers call them exercise snacks. These snacks can be as simple as going for walks.
21:45 Big surges glycemic variability/glycemic levels are a big problem.

Direct download: Exercise_May_be_the_Fastest_Way_to_Decrease_Blood_Sugar_and_Insulin.mp3
Category:general -- posted at: 11:33am PDT

Researchers at Stanford just published two of the most fascinating studies to date linking overweight/obesity with higher risk for severe COVID.

These related but different studies both find COVID (SARS-CoV-2) directly infects fat cells (concentrating virus) and cranking blood sugar and inflammatory processes. The findings have important public health implications if we're serious about saving lives. 

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Time Stamps:

0:00 Intro
2:32 InfectObesity 101
2:48 Study #1 Virus infects fat cells
4:22 Belly Fat is a problem
5:32 Infected fat cells trigger inflammation
6:20 Fat Cells altered in children
7:17 Endothelial Dysfunction and erectile dysfunction
7:52 Fat cells contain high levels of virus
11:04 Fat cell infection skews blood sugar
11:44 Omega-3 Index
14:01 Hyperglycemia from fat cell dysfunction
15:58 Fitness should be mandated
18:00 Key takeaways from study #2
20:00 Skewed leptin/adiponectin suggest fat cell is the problem
21:00 Restoring fat cell dysfunction

Direct download: Infected_Fat_Cells.mp3
Category:general -- posted at: 2:20pm PDT

Let's discuss the potential good news with regards to the recent variant of concern and how these mutations can lead to reduced severity of illness that's easier to catch.

We discuss the ACE2 receptor density in the upper VS lower airway and more.

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Time Stamps

0:45 Transmission VS Virulence Trade off
1:30 New mutations, what they mean
3:42 Location of ACE2: why it matters
4:31 Most important point of this paper
5:53 Testing Vitamin D at home
6:23 Details of the new mutations and ACE2
7:42 Upper airway infections are easier to transmit, catch
8:14 The transmission VS virulence trade off
9:52 ACE2 receptors have gradient densities in the airway
10:50 I could be wrong!

Direct download: Omicron_Mutations_a_Good_Thing.mp3
Category:general -- posted at: 5:54pm PDT

A large body of research suggests vitamin D impacts sleep quality and sleep duration as well as neurotransmitter levels in the brain. Here's an overview of the latest science--which is timely if you live in norther latitudes.

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Link to images, science and video: http://bit.ly/vitamin-d-sleep-science

Episode Time Stamps:

0:00 Intro
1:37 Vitamin D and Sleep
2:07 Dr. Stasha Gominak, MD Vitamin D and Sleep Podcast
2:16 Vitamin D and Gut Health
2:31 Vitamin D Metabolism Basics 
4:56 Factors that impact vitamin D levels
5:54 Optimal Vitamin D levels
6:42 Classical VS Non-Classical pathways linked with Vitamin D 
8:05 Vitamin D and sleep details
8:31 Vitamin D and sleep disordered breathing
9:05 Vitamin and sleep details
10:16 Vitamin D and Circadian Rhythms
11:00 Dosing Vitamin D at night
12:38 Vitamin D and Brain Development
13:45 Vitamin D is very important for children
14:57 Big picture re: Vitamin D and sleep
15:47 Vitamin D Blood spot test
16:13 Optimal Vitamin D levels this winter
16:50 Dosing Vitamin D prior to bed
17:52 Vitamin K and Vitamin D

Direct download: Vitamin_D_and_Sleep.mp3
Category:general -- posted at: 10:32am PDT

With all the buzz around boosters, family friends used data to help guide their family’s decision making process by testing their antibody levels and T cell immunity. We review their recent labs and discuss how data can and should be used to help you make health related decisions.

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Time Stamps: 

2:00 Booster hysteria: Is based on science

3:00 How much added benefit do boosters offer

6:00 Using data, not emotion, to drive policy

11:00 Reviewing families antibodies

14:10 Monica Gandhi MD, MPH on T cell VS B Cell Immunity

16:00 Reviewing antibodies and T Cells

20:00 Conclusion: using data to drive decisions

Direct download: family_gets_antibodies_tested_mixdown.mp3
Category:general -- posted at: 4:49pm PDT

Your body composition changes as you age, especially after menopause for women. Compressed feeding patterns like intermittent fasting (IF & TRF) can help improve metabolic health and prevent fat gain throughout lifespan. Deanna Mutzel joins us to discuss how she uses Intermittent Fasting and OMAD as a tool on busy days.

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Connect with Deanna: http://deannamutzel.com

Time Stamps

0:00 Intro
0:17 Fasting as a tool when life gets busy
1:34 Fasting can help with energy, mental clarity
3:15 Considering energy balance over a longer period of time
3:45 Undulating your calories
4:45 Vitamin D should be considered seasonally
6:39 Find out how snacking weak-spots
10:39 Getting the whole family on board
9:10 Using exercise to buffer glucose surges
12:01 Making your own chips
15:15 Walking "snacks" throughout the day
18:40 Changing your identity is important for success
19:49 Making exercise easier
21:47 Cold showers in the winter
24:00 Easing into fasting
25:30 Plant based diets and health
30:00 Changing your feeding window with the seasons

Direct download: Fasting_as_a_Tool_Over_40.mp3
Category:general -- posted at: 3:11pm PDT

Let’s review the long-known law of declining virulence which describes how viruses evolve to become less virulent over time as they infect more hosts.

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Episode Time Stamps:

3:15 Viruses mutate as they infect more hosts
3:40 Viruses are intracellular parasites
6:20 The law of Declining Virulence
7:25 RNA Viruses have high mutation rates
9:25 Are vaccines accelerating viral evolution?
11:45 The law of Declining Virulence details
14:05 Mild infections are selected for
16:00 Rising childhood infections are signs of endemicity
18:00 Russian flu pandemic of 1889
21:00 Mass vaccination during a roaring pandemic

Direct download: Omicron_OMG_Law_of_Declining_Virulence.mp3
Category:general -- posted at: 4:03pm PDT

Scientists in Italy find for the first time lower antibody levels in subjects with abdominal obesity. This suggests we ought to also be suggesting exercise and healthy living if we're serious about maximizing protection for everyone.

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Time Stamps

0:00 Intro
0:31 Belly fat and lower antibodies
2.02 Antibodies after natural infection VS not
6:40 Politics of Boosters
5:39 Personalized Medicine
6:20 Dr. Fauci on boosters
7:43 Central Obesity and Effectiveness
9:16 Vitamin D and winter
10:15 New study details
11:43 Image you should see
14:01 Antibody comparisons in family friends
14:33 Obese people shed more virus
15:47 Natural immunity VS enhanced immunity

Direct download: Boosters_for_all_.mp3
Category:general -- posted at: 11:01am PDT

A new study finds longer daily fasts were demonstrated to produce more favorable improvements in biomarkers that are associated with metabolic and cardiovascular health as well as inflammation.

Let's break it down...


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Links to notes: https://bit.ly/30WjpeE

REF:

Moro, T., Tinsley, G., Pacelli, et al. (2021). Twelve Months of Time-restricted Eating and Resistance Training Improves Inflammatory Markers and Cardiometabolic Risk Factors. Medicine and science in sports and exercise, 53(12), 2577–2585.


Time Stamps

0:00 Intro
0:18 New Study
0:08 Testing 16 Hour VS 12 Hour Feeding Windows
0:27 Markers of Inflammation decreased
1:17 Only four hour difference in feeding window
2:22 Study Title:
3:43 Testing your metabolic health
4:42 Berberine & metabolic health
5:50 Feeding Window comparisons
6:43 How Calories were distributed
7:36 Whey protein post workout
7:50 TRF group ate less calories by accident
8:33 Strength and muscle loss between two groups
11:08 Testosterone did decrease
11:53 Insulin, Leptin and Adiponectin
12:44 HDL, Triglycerides and glucose
13:52 Chronic Inflammation
15:11 Trade offs to consider

Direct download: 16_hour_VS_12_Hour_Fasting_Study.mp3
Category:general -- posted at: 10:52am PDT

Scientists recently found that metabolically protective brown fat—quantities of which are increased with deliberate cold exposure—can lead to meaningful increases in fat burning and metabolic rate.

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Link to research and images: http://bit.ly/brown-fat-helps

Time Stamps:


0:00 Intro
0:19 New study by Scientists in Japan
0:53 Not everyone has same amount of brown fat
1:29 How Brown Fat impacted metabolism
3:20 Vitamin D in the winter
4:17 Brown adipose tissue is under-recognized
5:08 Getting Cold in the AM is key
10:11 Getting Started with Cold Exposure
10:40 Circadian rhythm alignment
11:29 Morning cold may help PM sleep
11:57 Starting with a stock tank (sodium dichlor can help)
Wayne Pump:
12:57 Morozko Forge tank is the best
13:52 Getting cold helps induce the brown fat
14:53 Morning cold showers are ideal for fat loss
16:00 Brown fat increases the thermic effect of food
17:00 Brown fat helps increase fat oxidation after breakfast and lunch
17:52 Brown fat is more active in the morning then at night
18:36 Cortisol may help the brown fat activity
19:52 Brown fat is a metabolic sink
20:00 Free fats drive metabolic disease

Direct download: Brown_adipose_tissue_new_.mp3
Category:general -- posted at: 5:33pm PDT

A new study founds sugar consumption, less than seven hours of sleep nightly and sub-optimal exercise habits increase odds of being hospitalized. We breakdown this study and discuss the known science about how sugar impacts immune system health.

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Links to research: https://bit.ly/3oJCsRm

Time Stamps


0:00 Intro
0:12 New study
0:26 Sugar alters immunity
2:12 Healthy living saves lives
2:37 Active military member study takeaways
3:12 Study details
4:44 What the study found
5:06 Sugar weakens immunity
5:30 2/3s of Americans drink soda daily
6:28 Exercise was linked with lower odds of hospitalization too

 

Direct download: Air_Force_sugar_sleep_exercise_study_.mp3
Category:general -- posted at: 10:00am PDT

A fascinating series of studies highlights the importance of T cell health and T cell immunity. This timely reminder is important as the health of your T cells are influenced by age, nutrition, exercise and more.

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Time Stamps:

0:00 Intro
0:03 T Cells are important
0:43 But it's a new virus?!
158 T Cells Resist infections
2:02 New T Cell Study
2:20 T Cells depend on health
3:01 Hospital Worker Study
4:08 Blood Work MasterClass
4:35 Infected but no antibodies?
5:34 T Cells and Your Thymus
6:01 T cells and cellular senescence
6:51 T cells abort infections
7:42 Shared structure with other Endemic Viruses

Direct download: T_Cells_Abort_Infections_V2.mp3
Category:general -- posted at: 9:43am PDT

It’s common knowledge that calorie restriction is a validated strategy to extend lifespan and delay the onset of age-associated diseases. But there’s a new wrinkle that’s muddied the waters of this calorie restriction (CR) research, which, needless to say, has up to now been derived mainly from studies conducted in rodents (animal models).


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**Class starts Tuesday, November 16th 2021

Links to research: https://bit.ly/3wF4eSL

Study:

Pak, H. et al. (2021). Fasting drives the metabolic, molecular and geroprotective effects of a calorie-restricted diet in mice. Nature metabolism, 3(10), 1327–1341.

Time Stamps:

0:00 Intro
0:05 Shared Features of Fasting and Calorie Restriction
0:23 New Study
1:23 Big Omission from Calorie Restriction Data
2:40 Blood Work MasterClass
3:53 Testing Fasting VS Calorie Restriction study details
6:40 Fuel Switch with fasting
7:23 Insulin, Glucagon and fat oxidation
08:54 Metabolic profiling of different fasting patterns
10:38 Experiment Number 2
11:03 Lifespan extension in fasting VS CR VS Ad Lib
13:43 Match Carbohydrate intake with exercise
14:10 TRF Feeding pattern practical tips

Direct download: Fasting_VS_CR.mp3
Category:general -- posted at: 11:43am PDT

Scientists find lean subjects made protective antibodies after infection while obese subjects did not make protective antibodies—they made maladaptive autoantibodies instead. Researchers speculate that leptin plays a role in skewing the immune response toward autoimmunity after infection. Here's the details!

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Research, Images and Articles: https://bit.ly/3qsGYX6


Time Stamps:

0:00 Intro
0:09 Endemic Virus
0:59 Obese Don't Make Protective Antibodies
1:15 Obese people make autoantibodies
1:40 Leptin and Fat on Fire
2:40 Leptin exacerbates inflammation, autoimmunity
3:13 Study we're discussing
3:49 Make Americans Healthy Again
4:35 Blood Work MasterClass
5:30 Daniela Frasca, PhD: Obesity Hinders Immune System Response
6:10 Antibodies and BMI, C-Reactive Protein
6:43 Metainflammation and Inflammaging
7:15 Blood sugar and inflammation
8:13 Leptin and immunity
9:29 Summary of Study: immune tolerance breakdown
11:30 Lifestyle matters
12:30 Antibodies directed at fat tissue
12:52 Omega-6 Oils, Seed Oils & autoimmunity
13:50 Excess deaths related to heart disease on the rise
14:42 Image: CRP and autoantibodies
15:39 New study summary
16:21 Italy Research from fat cell spill over
16:58 Obesity is an autoimmune disease
17:05 Change your habits
17:47 Image: Behavior model

Books and References:

Tiny Habits: The Small Changes That Change Everything: https://amzn.to/3CbpvEQ

Frasca, D., Reidy, L., Cray, C., Diaz, A., Romero, M., Kahl, K., & Blomberg, B. B. (2021). Influence of obesity on serum levels of SARS-CoV-2-specific antibodies in COVID-19 patients. Plos One, 16(3), e0245424–16.

 

Frasca, D., Reidy, L., Romero, M., Diaz, A., Cray, C., Kahl, K., & Blomberg, B. B. (2021). The majority of SARS-CoV-2-specific antibodies in COVID-19 patients with obesity are autoimmune and not neutralizing. International Journal of Obesity, 1–6.

Direct download: Obese_Dont_Make_Protective_Antibodies_Study_Finds_.mp3
Category:general -- posted at: 6:16pm PDT

Here's an objective look at the latest science investigating the durability of immunity from prior infection plus results from serially testing antibodies after contracting COVID-19 in December of 2020.


Related: Save your seat in the Blood Work MasterClass Live Training eClass

This two-part live webinar and video eCourse will teach you about patterns and trends in your blood work to help optimize your health and lifespan.

Live Training Tuesday, Nov 16th @ 5:00 PM PST
Live Training Tuesday, Nov 30th @ 5:00 PM PST

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Links to resources and references: https://bit.ly/305VoS4

Time Stamps:

0:09 New CDC Study
1:07 Big Picture Overview
1:41 Antibodies 11 months later
3:05 CDC Study results differ from other data
3:26 T cell immunity
4:09 Innate VS Adaptive Immunity
5:05 Spanish Flu survivors have Abs 90 years later
5:50 Blood Work MasterClass Live
6:38 Testing Antibodies: how to do it
7:21 Why do we ignore prior infection
9:00 Number Needed to Treat in prior immunity VS Vaccine
9:58 Israel Data on reinfection rates
10:55 Cleveland Clinic study of 50,000
11:17 UCLA study of 6,000
12:11 Systemic Review of multiple studies o
13:30 Podcast recap

References:

Centers for Disease Control and Prevention. (2021). Laboratory-Confirmed COVID-19 Among Adults Hospitalized with COVID-19–Like Illness with Infection-Induced or mRNA Vaccine-Induced SARS-CoV-2 Immunity — Nine States, January–September 2021, 1–6.

RESEARCH NEWS: Antibodies To 1918 Flu Found In Elderly Survivors https://www.npr.org/templates/story/story.php?storyId=93675590
BMJ, J. B.,. (2021). Vaccinating people who have had covid-19: why doesn't natural immunity count in the US? Bmj.com. http://doi.org/10.1136/bmj.n2101&domain=pdf&date_stamp=13-9-2021

Shenai, M. B., Rahme, R., & Noorchashm, H. (2021). Equivalency of Protection From Natural Immunity in COVID-19 Recovered Versus Fully Vaccinated Persons: A Systematic Review and Pooled Analysis. Cureus, 13(10). http://doi.org/10.7759/cureus.19102
Kojima, N. (2021). Necessity of COVID-19 Vaccination in Previously Infected Individuals: A Retrospective Cohort Study, 1–22. http://doi.org/10.1101/2021.06.01.21258176

Kojima, N. (2021). Incidence of Severe Acute Respiratory Syndrome Coronavirus-2 infection among previously infected or vaccinated employees, 1–11. http://doi.org/10.1101/2021.07.03.21259976
Kojima, N., Health, N. S. E. T.,. (2021). A Systematic Review of the Protective Effect of Prior SARS-CoV-2 Infection on Repeat Infection. Journals.Sagepub.com. http://doi.org/10.1177/01632787211047932

 

Direct download: Durability_of_natural_immunity_.mp3
Category:general -- posted at: 10:23am PDT

A series of new studies find fat spill over from abdominal fat stores compromises liver and lung function, increasing risk of serious illness and death. Translation: losing belly fat and improving metabolic health should be a top priority for you. We discuss the details.


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Links to research and Video: https://bit.ly/3wk4beJ

Blood work cheat sheet: https://bit.ly/3dyy4zM

Time Stamps

0:00 Intro
5:55 Visceral Fat Study from Italy
6:34 Fat Embolism Syndrome (FES) and C*19
7:17 Overlap with Severe Disease and FES
7:58 Leptin, Overfilled Dead Fat Cells
9:04 Details of this new study
14:41 Sleep and Stress are important
15:36 Stressed Fat Cells Leak Lipids
19:26 Overfilled fat cells harm liver, lungs
20:52 Obesity, Insulin resistance and fat-cell leakage

Direct download: Belly_Fat_Immunity_Italy.mp3
Category:general -- posted at: 12:59pm PDT

Metformin and Rapamycin, two popular longevity drugs, have been shown to support immune health in elderly and high-risk subjects as well as decrease mortality in persons infected with COVID-19.

We discuss the science and rationale for prophylactic blood sugar health support in non-diabetics for longevity and immune health. 

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Related Podcast: Latest Breakthroughs In the Biology of Aging with Matt Kaeberlein, PhD

 

Time Stamps:


0:00 intro
0:38 mTOR inhibitors
1:15 Low Side effect profile
2:19 Metformin and influenza
2:50 Metabolic and immune health are one in the same
3:15 Aging and Immune Competence
3:52 Microdosing mTOR inhibitors
4:31 Dog Aging Project
5:07 Aging and Immunity
6:10 T Cells are Essential
6:55 Metformin was initially helpful for Influenza
8:11 Why chronic inflammation is bad
9:39 Pulsing mTOR inhibitors
13:38 Electrolytes and Creatine
14:19 Drugs are not always bad
15:28 Poor blood sugar control is a problem
18:20 Metformin and B Vitamins
19:15 Metformin and C*19

 

Articles Mentioned:

Bischof, E., C Siow, R., Zhavoronkov, A., & Kaeberlein, M. (2021). The potential of rapalogs to enhance resilience against SARS-CoV-2 infection and reduce the severity of COVID-19. The Lancet Healthy Longevity, 2(2), e105–e111. http://doi.org/10.1016/S2666-7568(20)30068-4

 

Bramante, C. T., Buse, J., Tamaritz, L., Palacio, A., Cohen, K., Vojta, D., et al. (2021). Outpatient metformin use is associated with reduced severity of COVID-19 disease in adults with overweight or obesity. Journal of Medical Virology, 93(7), 4273–4279.

Kruglikov, I. L., Shah, M., Elife, P. S.,. (2020). Obesity and diabetes as comorbidities for COVID-19: Underlying mechanisms and the role of viral–bacterial interactions. Elifesciences.org.

metabolism, A. S. D.,. (2020). Metformin and COVID-19: from cellular mechanisms to reduced mortality. Nutrition, Metabolism and Cardiovascular Diseases. http://doi.org/10.1016/j.diabet.2020.07.006

 


Let's breakdown this excellent article from Politico highlighting our double standard when it comes to public health policy.

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Link to this video, images: https://youtu.be/_Ijkdgva67g

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Show Notes:

0:29 The Politico Article

https://www.politico.com/news/2021/10/31/covid-deaths-diet-diseases-nutrition-america-517076

1:00 Governments and Big Food

1:42 Fast food packaging has endocrine disruptors

2:38 The connection with Chronic disease and C*19

5:40 Side effects of our safety measures

7:20 The irony of keeping kids safe

8:54 We things that keep us healthy

9:29 Doctors don’t understand obesity

10:33 Mandate fitness

11:47 How can we make change?

13:48 Listen to this!

14:16 Marion Nestle: the politics of food policy

Book by Marion: https://amzn.to/2ZTIwOG

16:00 Subsidizes inflate the cost of real food

18:21 Helping our friends get healthier

Direct download: Politico_Politics_of_Food.mp3
Category:general -- posted at: 4:55pm PDT

A new book dedicated to the topic of exercise as an autophagy enhancer makes the case that physical activity is a very important inducer of autophagy--a process very important for health and longevity--especially in the muscle, heart, liver and brain.

We review key takeaways from this book and practical applications. 

Support Healthy Hydration and Exercise Performance with the new Electrolyte Stix by MYOXCIENCE Nutrition: https://bit.ly/3uAWrV6

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Link to video, images and references: https://bit.ly/3mAR7Pb

Time Stamps:

0:07 Exercise influences autophagy

0:24 New Autophagy book

1:48 What is autophagy?
2:42 Conditions most benefited by autophagy

3:09 Cellular Trash

3:39 Autophagy Image

4:34 Exercise and autophagy chapter

5:45 Autophagy and your muscle

6:33 Autophagy and Mitochondria

7:03 Autophagy helps your muscles adapt

8:25 Autophagy and the heart

9:56 mTOR inhibition

10:06 Creatine, Taurine and Electrolytes

11:49 Exercise, Autophagy and your heart

13:38 Autophagy and your liver

14:08 Fatter liver assessment

16:03 Exercising in a low state is key

17:08 Fasted exercise

19:40 Dumping rusty mitochondria

20:54 Mitochondria in your heart

22:54 Exercise renews your mitochondria

24:12 Insulin resistance and muscle loss

26:02 Autophagy and fat loss

27:29 Lipophagy and hormones

Direct download: Autophagy_exercise_VS_Fasting.mp3
Category:general -- posted at: 8:40am PDT

A closer look at critics of FDA advisory committee member who abstained from voting on COVID vaccines for kids aged 5-11 and a new CDC report says vaccine confers better protection than natural immunity, let’s explore these topics and their nuances on deeper level.

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References for this discussion:

Boston Herald article that wrongly claims 17,000 kids under 18 years of age have died from covid-19 (the real number is less than 700): https://www.bostonherald.com/2021/10/29/fda-authorizes-pfizer-vaccine-in-kids-5-11-moving-it-one-step-closer-to-public-use

The actual state-level mortality data in Children from the American Academy of Pediatrics: https://www.aap.org/en/pages/2019-novel-coronavirus-covid-19-infections/children-and-covid-19-state-level-data-report

Discussion Drs Zubin Damania, MD and Vinay Prasad, MD, MPH with https://www.youtube.com/watch?v=SJ8fe3vtgfY


Link to CDC MMWR Report: https://www.cdc.gov/mmwr/volumes/70/wr/mm7044e1.htm?s_cid=mm7044e1_w

Direct download: Kids_Vax_VS_Evidence_Plus_New_CDC_Natural_Immunity_Report_.mp3
Category:general -- posted at: 8:47pm PDT

Scientists in Sweden analyzed health records in over 279,000 subjects who had prior documented fitness and body fat screenings.

They found strong, independent associations with low fitness levels and higher belly fat with increased odds of severe disease.

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Link to studies, images and video: https://bit.ly/30UiScO


Time Stamps:

 

0:00 intro

 01:46 Increased levels of underlying health conditions are independently correlated with the risk being hospitalized and dying.

REF: Ekblom-Bak, E., et al. (2021). Cardiorespiratory fitness and lifestyle on severe COVID-19 risk in 279,455 adults: a case control study. International Journal of Behavioral Nutrition and Physical Activity, 1–16.

02:30 Physical inactivity is associated with a 32% increased risk for being hospitalized from SARS COVI2. 10% of COVID hospitalizations were linked to physical inactivity alone.

03:30 People who were physically inactive in the 2 years leading up to COVID 19 outbreak, had a significantly higher chance of being hospitalized, admitted to the ICU and dying from COVID 19, compared with those who reported 150 cumulative minutes of exercise over the course of a week.

REF: Sallis, R. et al. Physical inactivity is associated with a higher risk for severe COVID-19 outcomes: a study in 48 440 adult patients. Br. J. Sports Med. https://doi.org/10.1136/bjsports-2021-104080 (2021).

04:45 25 to 30% of skinny people are metabolically obese, with fat in and around their organs. It is ectopic fat deposition. Visceral fat is independently corelated with increased risk of many diseases and poor outcomes with COVID 19.

05:26 Visceral adiposity is associated with severe COVID 19. Subcutaneous fat was not.

Pranata, R., et al. (2021). Visceral adiposity, subcutaneous adiposity, and severe coronavirus disease-2019 (COVID-19): Systematic review and meta-analysis. Clinical Nutrition ESPEN, 43, 163–168. http://doi.org/10.1016/j.clnesp.2021.04.001

06:40 The rate at which children have become overweight has more than doubled since the COVID 19 outbreak.

07:33 Exercise reduces the risk of developing the underlying health conditions that are associated with poor outcomes.

REF: The Big Mistake of not Considering Physical Activity an Essential Element of Care During the Covid-19 Pandemic. (2021). International Journal of Cardiovascular Sciences.

08:00 Many of our immune cells are susceptible to cellular senescence, irreversible growth arrest. Senescent cells release biologic pheromones, attracting other cells to become senescent. Senescent cells accumulate during ageing and accelerate ageing.  

11:55 The COVID 19 death rate reported in the Sweden study was .03%, even with open schools and no mask mandates.

12:49 People who contracted COVID 19 in Sweden generally had higher BMI, waist circumference, blood pressure and increased numbers of underlying health conditions.  They were often daily smokers, had lower VO2 max scores, and less favorable exercise patterns compared to those who did not become ill.

13:38 Being overweight was associated with a 2-fold increased odds, and being obese or severely obese was associated with a 3-fold increased odds of having a severe COVID case, compared with those with normal waist circumference.

14:16 Underlying health conditions had the greatest increase in odds, 1.88 for one diagnosis, up to a 4.55 greater increased odds with those with 4 to 5 chronic diseases.

14:41 High psychologic stress was associated with a 1.36% increased in odds of severe COVID. Daily smoking increased odds for severe outcomes .6%.

15:00 There are strong associations of several lifestyle related risk factors, including cardiorespiratory fitness, being overweight or obese, perceived stress and high blood pressure with severe COVID 19.

Direct download: Exercise_Healthy_Living_Saves_Lives_too_Sweden.mp3
Category:general -- posted at: 1:17pm PDT

Dr. Elly Michelle works with a lot of women who've experienced hormone issues and mental cycle changes from overexercise and under-eating. She discusses how scaling back on the cardio, prioritizing weight lifting and eating healthier whole foods can improve hormonal health, fertility and body composition.

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Link to video: https://youtu.be/AbAGSIDzL7A

 

Time Stamps:

0:00 Intro
03:10 Dr. Elly ate no meat for 10 years
03:52 Chronic low estrogen impacts bone health.
05:00 As Dr. Elly began strength training and, as she became stronger, she craved meat.
07:37 You can be spiritual about eating meat.
10:45 From eating a plant-based diet, Dr. Elly experienced poor hormone health, poor thyroid health, low energy, digestive issues, anxiety, lack of muscle and low libido.
16:30 Menstrual cycle hormones are protective of long-term health.
21:10 PMS is primarily reflective of a hormone imbalance.
25:35 Ovulation is required to produce progesterone, an anti-stress hormone.
28:00 Irregular periods do not mean that you are ovulating.
29:00 Estrogen dominance is when estrogen is unopposed by progesterone, not necessarily an over-abundance of estrogen..
33:30 Your hormones are responding to your environment. They are not to blame.
35:05 Estrogen imbalances contribute significantly to anxiety.
38:00 Someone who is in optimal health, will be fertile. Calm and joyful socialization helps to optimize hormones and fertility.
43:01 Regular bowel movements are important for detoxification and removal of hormones.
45:00 Strength training supports your metabolism.
52:43 Basal body temperature first thing in the morning (for women) is a measure of metabolic health.
55:30 Most women ovulate on about day 14 of a 28-day cycle. The fertile window is 5 days before and 5 days after ovulation.
58:20 Anxiety is linked to severe C*19 outcomes.
01:01:20 Take your recovery and sleep as seriously as you take your training.
01:04:10 Fasting may not be a good strategy for those of us with hormonal imbalances or fertility issues.
01:14:03 Libido is a reflection and expression of health for both men and women.
01:15:43 Testosterone and estrogen are drivers of libido for women. Estrogen is responsible for sexual lubrication in women.

Direct download: Elly_Michelle_Weight_Lifting_for_Women.mp3
Category:general -- posted at: 1:44pm PDT

Blood viscosity is a silent driver of cardiovascular disease and stroke. It's very common for men of all ages and post-menopausal women to have increased blood viscosity. In today's show we dive into the science you need to know about testing blood viscosity and reducing risk of heart disease.

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Link to research and show notes: https://bit.ly/3GbYd4p

Link to video: https://youtu.be/gabXVh9Ig5U


0:00 intro
0:10 Blood Viscosity and heart disease
0:19 Blood Viscosity and infections
0:45 Hematocrit and Hemoglobin
1:26 Blood Viscosity and infections
3:18 Blood Viscosity and Antibodies
4:34 What is Blood Viscosity?
6:37 Testing Blood Viscosity
8:33 Hydration is important
9:41 Blood Viscosity during an infection
12:33 What causes Blood Viscosity
18:31 History of Blood donation
23:25 Blood Work MasterClass
25:27 Blood Viscosity and C*19

 

Direct download: blood_viscosity_.mp3
Category:general -- posted at: 11:01am PDT

Various studies have found a correlation with obesity, poor metabolic health (insulin resistance) and higher viral loads and spread. In this session we summarize this body of research, suggesting it's our moral obligation to get and stay physically fit, metabolically healthy.

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Link to Video, Images and Show Notes: https://bit.ly/3B2Jfd5


Time Stamps:

0:00 intro
0:45 Viral load and Obesity
1:20 Fast food companies
2:40 Gut health and infections
2:48 Fast food is part of the problem
5:47 Eating local, why it’s important
7:37 High glucose increases viral load
8:57 Importance of HBA1C
9:26 Influenza and Obesity

9:58 Obesity may drive viral variants
10: 17 Viral load and Obesity
11:40 New Electrolyte
12:37 Viral load and Obesity
14:00 Mike’s infection story
16:53 IL-6, Inflammation and viral load
18:43 Viral Load and high blood pressure, Obesity
20:30 Viral load and BMI
23:28 Obesity, Leaky Gut and Lung Issues

Direct download: metabolic_heatlh_and_viral_load.mp3
Category:general -- posted at: 10:02am PDT

Sal Di Stefano, author of “The Resistance Training Revolution,” discusses the latest science about how building muscle is the best weight-loss strategy and reviews new research about how muscle signals your body to burn fat directly.

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Get Sal's New Book: https://amzn.to/3AMfhKb

Video Version of this Show: https://bit.ly/3AUoT5S

Time Stamps:

0:00 intro
03:10 Rigidly structured nutrition is not sustainable.
05:00 We take nutrition advice from people with extreme physiques.
07:02 We do not have a weight loss issue. We have a problem keeping weight off.
14:10 Resistance training is a superior form of exercise for fat loss, heart health, and insulin resistance.
14:50 Resistance training stopped the progression of beta amyloid plaques that cause Alzheimer’s, according to an Australian study.
17:40 Resistance training is using resistance specifically to build strength and muscle.
19:00 Running is a skill that needs practice and instruction.
20:05 Resistance training is all about form and technique.
24:30 The calorie burn during exercise is not very important in cardio because your body prioritizes energy conservation and efficiency.
26:00 Roughly half of the weight you lose with cardio, is muscle.
27:01 Strength training creates a less efficient, faster metabolism.
29:32 Weight lost through resistance training is body fat.
30:30 All you need is two days a week of resistance training to bring strength, tone and a faster metabolism.
32:30 Muscle memory: Building muscle the first time may take a while. Losing that muscle is slow. Regaining it is much faster than the initial buildup.
44:20 Gross motor movement compound exercises are most effective for building muscle.
45:50 Your central nervous system controls how your muscles fire, your strength and stability.
48:10 Proprioception, knowing where you are in space, increases with resistance training.
51:00 Resistance training elicits immediate and long-term hormonal responses.
51:35 Resistance training is the only pro-tissue form of exercise.
53:35 Resistance training reliably increases androgen receptors in men and women.
55:55 Low testosterone increases cancer risk, increases risk of heart disease, increases Alzheimer’s and dementia risk, decreases quality of life.
56:48 The average 25-year-old male today has the testosterone levels of the average 60-year-old in 1980.
57:00 A 20-year-old male today have the grip strength of a 60-year-old in 1980.
57:50 Grip strength can predict all-cause mortality better than any other single metric.
01:05:30 Pushing yourself to maximum performance is counter longevity.
01:07:00 A low protein diet generally reduces longevity.
01:09:55 Obese people have weaker bones, less muscle and more bodyfat.
01:10:30 What builds muscle, builds bone.
01:17:50 Resistance training is in the elderly improves cognitive function and hormone profiles.

Direct download: Sal_Muscle_Doesnt_Tone.mp3
Category:general -- posted at: 3:30am PDT

Joe Rogan asks Dr. Sanjay Gupta of CNN hard questions you've been seeking answers for. I found these five clips to be among the most informative from this three hour long discussion, yet they were not covered in the news coverage about this conversation. 

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Video Version: https://youtu.be/HI8L8uhnSic

Time Stamps:


1:30 Joe Rogan addresses the root cause
2:56 Joe & Dr. Gupta on Obesity, Health & 80% of cases are mild
4:32 Dr. Gupta admits we should focus on health
7:17 Dr. Gupta agrees processed food is a problem
10:50 Pandemic of Junk Food Excess
11:21 Vitamin D and K
12:18 It’s a Vascular Disease & aspirating the needle

12:41 More on Heart Disease and more
14:35 Obesity and blood vessels
17:00 Myocarditis in kids breakdown
19:37 Data in kids from last 19 months
23:24 We’ve made kids more vulnerable
24:33 Natural Immunity: why is it still ignored.

Direct download: Rogan_Gupta.mp3
Category:general -- posted at: 10:14am PDT

Metabolic Health should be a top priority for everyone, now there's a new easy at-home test kit to give you insights.

Save on this at-home A1C test by Biocoach: https://bit.ly/at-home-A1C-test
Use code HIH5

Time Stamps:

0:00 Intro
1:00 Hemoglobin A1C 101
1:49 Why you should care about your HbA1C
2:30 A1C Links with diseases
6:00 Hemoglobin A1C details
7:00 Testing your Hemoglobin A1C at home

Direct download: A1c_at_home.mp3
Category:general -- posted at: 4:02pm PDT

When it comes to weight loss, there's two primary models to explain the best strategy: The carbohydrates-insulin model and the calorie imbalance, also known as the CICO model. In this show we discuss the strengths and weaknesses of these models and how to best approach fat loss.

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Link to Show Notes, Video and Articles: https://bit.ly/3BxR63o


Time Stamps:

01:35 Physicians are taught that weight loss is only triggered by caloric restriction. It is the traditional energy balance model.

02:00 The traditional energy balance model does not consider your circadian rhythm or phenotypes, like those of us who over-excrete insulin, have epigenetic factors, or have adaptive thermogenesis.

02:20 Cyclical dieting down regulates your resting metabolic rate, adaptive thermogenesis.

03:20 The carbohydrate/insulin model of obesity is centered around insulin. Hyperpalatable ultra-processed high glycemic foods increase the energy circulating in your blood, causing a compensatory hyperinsulinemic physiologic state. This causes a decrease in the amount of nutrients in your bloodstream after you eat. Your blood energy reduces to levels below before you ate, causing hunger and over-eating at the next meal.

05:35 Cellular semi-starvation: In a high sugar/high insulin state, fat cells accumulate energy intended for the now insulin resistant muscles, they undergo lipogenesis, storing lots of energy. Therefore, there is a lack of energy in the bloodstream. Your brain believes that your critical tissues are starving.

06:40 Hormones surge in this state of cellular semi-starvation; there is a surge of adrenaline, noradrenaline, and cortisol.

07:10 In drugs that increase insulin, insulin signaling caused fat gain of up to 5 pounds in a 2-month period.

07:35 The energy balance model considers all calories as metabolically equal.

08:05 Hyperpalatable ultra-processed high glycemic foods lend themselves to overconsumption and hormone alteration.

08:20 Energy intake is regulated by insulin, hunger satiety cues from the brain, leptin, ghrelin, and habits. A few nights of poor sleep increases hunger.

09:00 The more lean muscle mass you have, the more you increase your resting metabolic rate.

10:00 Insulin is pleiotropic, meaning it does many different things within your body.

13:50 Biggest Loser 6 year follow up study revealed that many participants continued to gain wait after their participation in the program’s rapid weight loss. When they regained their weight, their resting metabolic rates were depressed lower than when they started.

15:45 The energy balance model works best for young fitness competitors and bodybuilders.

16:40 A high glycemic diet increases levels of glucose in the blood, causing alterations in gut hormones and the insulin to glucagon ratio.

17:10 To get into a fat burning physiologic state, you need low glucose, low insulin and elevated glucagon. The insulin to glucagon ratio helps to unlock stored fat, increases your liver’s synthesis of ketones, and helps your white fat behave more like brown fat, increasing your resting metabolic rate.

20:00 Weight centered approaches to weight loss does not lead to lasting improvements in muscle mass or cardio-respiratory or favorable changes in overall health risk.

20:43 Sustainable changes are made when focusing on improving fitness, strength, muscle mass, sleep quality, HRV lead, independent of weight loss.

21:00 Physically fit people, no matter their weight, have a significant reduction in all-cause mortality compared to unfit individuals of the same body weight category.

22:34 Weightlifting and interval training are better ways to reduce all-cause mortality and risk for severe COVID, improve cardio-respiratory fitness and better way to help with fat loss.

26:20 Eating less causes adaptive thermogenesis. Instead, you could practice time restricted feeding and eat higher quality food.

Direct download: Insulin_VS_Calories_and_Weight_Loss.mp3
Category:general -- posted at: 10:48am PDT

Scientists recently uncovered various ways mitochondria support immune health via anti-viral properties. We discuss this research and why health experts should be emphasizing exercise and fasting as strategies to improve mitochondrial, and thus immune, health.

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Link to research, images and video: https://bit.ly/3FwQopn

Time Stamps:

00:54 Your mitochondria play an important role in your body’s innate immune system mounting an antiviral immune response.
01:20 Lifestyle interventions impact the health and function of your mitochondria. Mitochondria are powerful in preventing several diseases, including infectious disease. These include fatty liver disease, obesity, heart disease, diabetes, neurodegenerative diseases and even cancer.
02:18 Mitochondria are intracellular organelles. They are responsible for making energy (ATP) for your cells.
03:40 If you have poor mitochondrial health, your cells do not have sufficient energy, and you may have insulin resistance, fatigue, or brain fog. It may mean that you will not release sufficient antiviral peptides when you are exposed to a pathogen.
05:00 Physical activity is protective against death, hospitalization, and severe disease.
05:24 Mitochondria are important for liver health, brain health and metabolic health.
06:55 Beneficial affects of regular physical activity on immune function are at least partly mediated by mitochondrial fitness. Low mitochondrial fitness and low cardiorespiratory fitness may be important risk factors for COVID 19.
07:30 Poor mitochondrial health may be a link between established risk factors like age, underlying health conditions like obesity, high blood pressure, diabetes, and other chronic disease.
07:43 Physical activity or targeted pharmacological intervention that increase mitochondrial capacities likely increase mitochondrial function and may enhance innate immunity. Taking berberine or metformin prior to exposure has been shown to reduce risk for severe outcomes in COVID. Metformin is more protective in women than in men.
09:11 Individuals with poor cardiorespiratory fitness have increased risk for severe disease, hospitalization, requirement for being on a ventilator and death.
09:42 Low physical activity is linked with contracting COVID 19 and poor outcomes.
10:25 Mitochondria are critically involved in antiviral host responses.

Direct download: Mitochondria_Antiviral_Properties.mp3
Category:general -- posted at: 1:17pm PDT

Research continues to emerge in support of time-restricted feeding (TRF) as one of the most powerful types of intermittent fasting.

Support Your Fast with the Berberine HCL + Lipoic Acid and Biotin stack by MYOXCIENCE: https://bit.ly/berberine-biotin-ala-stack

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About Today's Show: 

Because TRF restricts food intake to certain times of the day, it syncs our circadian clocks with processes involved in life span extension, like autophagy.


Links to Research Highlighted:
https://bit.ly/3iDZw1M


Time Stamps


0:00 Intro
0:22 TRF, Autophagy and Circadian Rhythms
01:33 Circadian Rhythms, TRF and Autophagy Study
04:07 TRF benefits depend on Circadian Rhythms
04:54 Your Circadian Clock and Metabolism
09:20 Eating windows and metabolism
13:08 Temperature and Circadian Rhythms
14:45 Berberine and Autophagy
15:52 early Time-Restricted Feeding (eTRF) and Longevity
17:46 TRF and weight loss
19:15 New TRF and Lifespan Extension Study

Direct download: eTRF_Circadian_rhythms.mp3
Category:general -- posted at: 11:44am PDT

Scientists in the UK discovered a novel way the Spike protein of SARS-CoV-2 may cause microvascular disease. These discoveries should emphasize healthy lifestyle change, smoking cessation, exercise, walking and sauna therapy as preventative measures to lessen the potential vascular damage during the course of infection.

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Direct download: S_Protein_and_EDC.mp3
Category:general -- posted at: 11:01am PDT

We review new autophagy research and discuss ways to measure this process to see if your exercise, nutrition, fasting windows are sufficient to support this critical cellular clean-up process/

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Time Stamps:

01:26 Autophagy and the body

02:42 mTOR and Autophagy

03:19 Snacking and Autophagy

04:06 AMPK is the gas pedal on autophagy

05:10 Exercise and autophagy

06:20 Berberine and Autophagy

06:56 Measuring Autophagy

07:20 Lipophagy and fat loss

08:22 Autophagy and the liver

09:35 Autophagy and Muscle

10:23 Great Autophagy Review Paper

10:50 Autophagy and Age

11:50 Autophagy and Immunity

12:38 Autophagy and muscle loss

Direct download: Autophagy_assesment_and_testing.mp3
Category:general -- posted at: 8:33am PDT

We’re hearing a lot about misinformation surrounding vaccines, but what about misinformation about general health and nutrition habits, especially among healthcare workers themselves? We review two of these viral stories and discuss our bias as a society when it comes to chronic disease prevention.

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References:


Time Stamps:


0:00 Intro
0:30 Training is lacking basic health
2:00 Obesity is a problem amongst health care workers

” prevalence study of nurses in Scotland found that 69% were overweight or obese, and obesity was significantly higher among nurses than other healthcare professionals and those working in non-health-related occupations,” Kelly, M., Medicine, J. W. O.,. (2018). Systematic review: What works to address obesity in nurses? Academic.Oup.com
. http://doi.org/10.1093/occmed/kqy038

3:00 Doctors don't eat healthy foods

O’ Keeffe, A., Hayes, B., & Prihodova, L. (2019). “Do as we say, not as we do?” the lifestyle behaviours of hospital doctors working in Ireland: a national cross-sectional study, 1–15. http://doi.org/10.1186/s12889-019-6451-8

4:00 India and Natural Immunity
5:00 Belly Fat and V Effectiveness
6:00 Idaho Nurse Story

9:00 Ways we can be healthier, practically 

Direct download: Nurse_nutrition_missinformation.mp3
Category:general -- posted at: 11:55am PDT

As you age the quantity of protective types of fat, known as brown fat and beige fat, decline leading to a worsened in blood sugar control, weight gain and inflammation.

In today’s show we dive into emerging science linked with preserving this protective type of fat.

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Time Stamps

0:00 Intro
0:20 Brown fat declines with age
1:03 Brown Adipose Tissue in Obese Children
2:23 Berberine, Ketones and Brown Fat
3:37 Less Brown Fat More Inflammation
4:56 What is uncoupling and heat creation
6:11 Where is Brown Fat Found
7:00 As adults we're no longer stimulating brown fat
7:42 Beige VS brown fat
9:40 Brown fat is metabolically protective
11:26 Exercise and fat cell thermogenesis
11:50 Fat cell thermogenesis and circadian biology
13:02 How to get more brown and beige fat

Direct download: Brown_Fat_Cold_Thermogenesisn.mp3
Category:general -- posted at: 3:06pm PDT

It sounds crazy, but your Intermittent Fasting window should ideally change with the season: shorter days translate into shorter feeding windows. Longer days, longer feeding windows. We discuss the science and rationale to support this idea of seasonally adjusted feeding.


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Direct download: Best_Feeding_Window.mp3
Category:general -- posted at: 11:59am PDT

Short-sided pandemic policies fueled a surge in Overweight and Obesity rates in both Children and Adults across the USA, new CDC reports find.

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Time Stamps:

0:47 First report showing Childhood obesity rates have doubled
1:28 New CDC report—Obesity Rates have skyrocketed
2:02 460 Kids have died from C*19
2:58 Millions of kids are now more overweight
4:44 JAMA Article, Obesity Rates in kids
5:38 Details of the CDD Findings
6:56 Bad Pandemic Policies are the problem
7:50 Obesity rates in kids, details
8:39 Preventing obesity in the first place is best
9:36 Recidivism and Obesity
14:28 Why gym closures were bad
15:53 Obesity rates in adults got worse, too

Direct download: Obesity_Rates_Surge_in_adults_kids.mp3
Category:general -- posted at: 10:42am PDT

Intermittent fasting and prolonged fasting decrease insulin but also impact your thyroid, cortisol and other hormones. In this show discuss this research and considerations when deciding how often or long to fast for your health.

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Time Stamps


0:00 Intro
01:39 Prolonged fasting impacts hormones and your circadian rhythm.
02:22 Fasting may not be beneficial in general for metabolically healthy individuals who are physically active.
02:52 Fasting benefits those of us who have significant body fat to lose.
03:37 Insulin drops about 35% over a 24 hour fast. It is halved after 72 hours.
04:22 Create a fasting plan that is sustainable and consistent.
05:27 Your metabolic rate is reduced during fasting. Thus, there is a somewhat significant reduction in free T3 levels and a reduction in TSH with fasting.
06:07 Autoimmune hypothyroidism is characterized by leptin interfering and changing immune system tolerance.
07:07 If you are lean and have thyroid issues, perhaps fasting is not of benefit to you.
07:17 Early time restricted feeding pushes your circadian rhythm into an early robust cortisol waking response.
07:52 Fasting, eating, and waking up causes a transient increase in cortisol.
08:37 The primary benefit to fasting is a reduction in glucose and reduction in insulin.
08:52 Early time restricted feeding that Mike recommends, consists of breaking your fast at about 10 a.m. and ending by 6 p.m.

Direct download: Fasting_and_the_thyroid_insulin.mp3
Category:general -- posted at: 11:11am PDT

Politicians and health officials continue to create new mandates and health orders but curiously ignore rampant obesity and metabolic health issues. Meanwhile, scientists carry on with publishing new research about the protection offered by exercise and healthy living.  


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Time Stamps:


0:34 Commonalities among the hospitalized
0:44 Obesity Epidemic in America
1:14 Fauci promotes healthy living in 2019
2:08 Healthy living has been ignored
2:41 Scientists: we’ve worsened Obesity in 2020
3:32 Mechanisms driving Obesity
4:45 Biden, Boosters and the FDA
5:20 Deaths in 2021 are no worse than 2020
7:14 Farm bill and agriculture subsidies
8:04 Belly Fat and V efficacy
8:34 Obesity and the Pandemic from Mayo Clinic
10:41 Society is Biased towards acute infection
13:55 Vitamin D levels in the fall and winter
14:40 WebMD ignores obvious obesity
15:50 Common features of hospitalized people
19:00 CNN visits hospitalized patients, ignores obvious health issues
19:38 We’ve worsened Obesity
20:08 Woman does everything right, still got sick
20:40 Why is the media ignoring this
22:57 We’re fattening our kids with Junk food in schools
25:07 Children are move overweight than ever
25:45 60% of the calories kids eat is junk
26:00 Health experts promote exercise
26:48 New study finds exercise is protective against hospitalization
28:00 Exercise enhances V effectiveness

Direct download: Unfit_and_Overfed.mp3
Category:general -- posted at: 8:24am PDT

A new study unveils details about how sauna therapy supports longevity, heart health and preservation of muscle mass throughout lifespan. In this podcast we review these findings and discuss the practical ways to benefit and incorporate into your life. 

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Time Stamps

01:00 Each type of sauna is beneficial. With infrared, you need to stay in longer for similar benefits.
02:30 There is a 65% risk reduction for mild cognitive impairment and Alzheimer’s in people who sauna 3 to 5 times each week.
02:45 There was a 27% lowered risk for cardiovascular disease in men who used the sauna 3 to 5 times a week.
03:00 There was a 50% lower risk of cardiovascular disease in men who used the sauna 4 – 7 times a week.
03:45 Length of time in the sauna: Mike advises that you stay until you feel uncomfortable and then stay another minute. Take a break and then go back in.
04:00 A sauna inside your home needs good ventilation to prevent mold.
05:00 Sauna therapy shifts about 60% of your blood from your core to your periphery and skin. The inverse is true when you get cold in contrast therapy.
07:10 Loss of control of protein balance within the cell, loss of proteostasis is a hallmark of ageing. There is benefit within the muscle tissue in reducing atrophy of the muscle with sauna therapy.
08:10 Heat shock proteins are involved in preventing the accumulation of dysfunctional protein.
09:20 Heat therapy and sauna bathing can help to decrease age-related muscle loss.
09:30 Individuals with high blood pressure have dysfunctional endothelium, which causes erectile dysfunction.
12:10 Heat shock protein expression can be increased for up to 48 hours with sauna use. This response shifts upward as you become more acclimated to heat therapy.
13:15 Transient increases in interleukin 6 are favorable. There is also a transient increase in interleukin 6 with heat therapy.
14:15 Interleukin 10 affects your T-regulatory cells, which help to increase tolerance within your immune system.
16:10 Sauna therapy improves sleep and heartrate variability.
17:30 Sauna bathing enhances the excretion of cadmium, lead and other heavy metals in the sweat.
18:00 You also release beneficial minerals in sweat: magnesium, zinc and sodium.
19:15 Sauna use can negatively impact sperm motility.

 

Direct download: Sauna_and_lifespan.mp3
Category:general -- posted at: 3:00am PDT

Scientists published a new study finding Berberine HCl supports blood sugar and metabolic health by acting synergistically with Bifidobacterium probiotics and possibly fermented foods. We unpack the details and discuss best practices with Berberine HCl dosing for fasting and beyond.

Link to show notes: https://bit.ly/3A69jnR

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Time Stamps

 

0:12 Synergism with Berberine HCl & Probiotics

0:40 Ferments and Probiotics

1:38 New Berberine Study and Probiotics

2:19 Study Details

3:11 Dose of Berberine

3:29 Berberine and Exercise

4:21 Berberine and Probiotics

6:19 Using Berberine to kick-start fasting

6:48 Berberine and the gut, absorption

7:00 How natural compounds impact health via the gut

Direct download: Berberine_HCl_and_Gut_Bacteria.mp3
Category:general -- posted at: 12:22pm PDT

A fascinating new study found correlations with NK Cell activity, vitamin D status and exercise habits. Since NK cells are a vitally important first-line defense against pathogens, these findings have timely, real-world implications.

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Time Stamps:

0:00 Intro
01:15 Your adaptive immune system provides immunologic memory.
01:40 Natural killer cells are part of your innate immune system, which has no memory and provides an all or nothing response.
01:50 Increased expression of innate immune system activation is found with obesity, insulin resistance, hypertension, and other chronic inflammatory diseases.
02:55 Overweight individuals tend to have a higher viral load.
03:10 Natural killer cells deal with pathogens, bacteria, and viruses and cytokines released by natural killer cells, help to signal your adaptive immune system.
04:00 Natural killer cells are important in preventing cancer.
04:15 Vitamin D and exercise are major determinants of natural killer cell activity.
04:40 Age, gender, vitamin D and exercise are associated with immune function determined by natural killer cell activity.
04:45 Age was a determining factor for low natural killer cell activity in men, but not women.
05:10 Sufficient levels of vitamin D reduced risk of low natural killer cell activity in men.
05:30 Exercise reduced risk of low natural killer cells in women and in both men and women over the age of 60.
05:45 A natural killer cell assay is not commercially available here in the US.
07:30 Decreased natural killer cell function in immunologically normal elderly is associated with increased risk for severe infections and mortality in general.
07:40 Natural killer cells may play a critical role in the early immune response.
08:20 An exhausted innate immune system can become depleted with a severe infection.
10:20 Medium to high intensity exercise decreased the risk for very low natural killer cell activity in women.
11:50 The vitamin D level sweet spot appears to be between 40 and 60 nanograms/ml.
13:25 Low natural killer cell activity in women did not seem be impacted by age as much as with men.
13:55 The size of your thymus gland and the amount of T cells that you produce decline (immunosenescence) as you age. Natural killer cells may compensate for this.
14:40 Over-exercise is associated with greater odds of low natural killer cell activity.
15:30 Vitamin D deficiency and insufficiency were associated with increased susceptibility to COVID-19
17:00 Immune system assays are expensive. You can triangulate looking at things like white blood cell count, C-reactive protein.
20:45 Each 1 unit increase in BMI, reflected a 12% increase in the risk for severe COVID-19.

 

Direct download: NK_Cells__Vitamin_D_and_Exercise_.mp3
Category:general -- posted at: 1:42pm PDT

Cold exposure has many health (metabolic and immune) benefits. We catch up with Adrianne and Jason of Morozko Forge to discuss the many health benefits linked with cold therapy.

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Link to Video, Notes and Resources:

Key Time Stamps: https://bit.ly/2YwOkwK


0:00 Intro
0:20 Acclimating to cold
2:08 Vitamin D Levels Decline in the Fall
3:00 Cold plunge and metabolic health
2:53 Cold and Circadian Rhythm
3:54 The Best Plunge
4:00 DIY Stock tank
4:19 Why the Morozko Forge
4:58 The Shivering response
5:30 Starting with cold showers
5:58 Fat loss and cold exposure
21:30 How Morozko Forge Started
24:17 Benefits of Hormetic Stress
30:20 How long to plunge
34:00 the power of cold
37:00 Best time to plunge
31:50 Cold and the Brain
47:27 Using cold to enhance circulation
52:16 How Adrienne used cold exposure to heal her autoimmune conditions
60:00 Depression and cold exposure
1:03:00 Keeping your plunge cold and clean
1:08:00 Shivering with the cold

Direct download: Surprising_Health_Benefits_of_Cold_Exposure.mp3
Category:general -- posted at: 12:42pm PDT

People often say, “kids are resilient.” However, scientists find children gained 23.9% more fat as a result of school closures in 2020. We also discuss a new paper suggesting poor metabolic health may be to blame for emergent viral variants and more. 

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Time Stamps:

0:00 Kids body fat surged during the pandemic
2:25 Vitamin D Health Benefits
2:57 Obesity and Recidivism
3:41 Why aren’t parents concerned?
4:00 Kids and Mortality from the virus
4:40 Kids and metabolic health
5:43 Obesity and the virus in adults
6:19 Stay home order caused weight gain
7:45 Why Obesity is a problem
9:10 Obesity environment and virulent virus strains
10:20 Viral load and obesity
12:18 Rates of Obesity in Kids skyrockets during pandemic
18:39 Response to Obesity Crisis is insufficient
20:20 Infection course in kids and co-morbidities
22:12 Diabetes Prevalence in kids is up 95%

Direct download: Obesity_Kids_2020.mp3
Category:general -- posted at: 12:23pm PDT

We review top news this week from outbreaks in Israel, new findings about transmission dynamics in vaccinated subjects and the media’s response to Joe Rogan crediting Ivermectin as part of his protocol in successfully overcoming COVID in just three days.

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Direct download: Joe_Rogan_Crushes_COVID_in_3_Days_Media_Melts_Down_.mp3
Category:general -- posted at: 7:18pm PDT

Researchers in Israel published a pre-print comparing reinfection rates VS breakthrough cases in thousands of fully vaccinated individuals. Let’s dive into their findings!

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Direct download: Natural_Immunity_VS_vaccine_Immunity_.mp3
Category:general -- posted at: 9:59am PDT

Scientists in Italy find, for the first time, increased abdominal fat is linked with significantly lower quantities of antibodies compared to subjects with healthy quantities of belly fat. We these details and a new report noting V effectiveness has declined from 91% to just 66% in recent months.

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Time Stamps


0:00 Intro to study
0:13 Belly Fat and Effectiveness
0:30 CDC report
1:40 Increasing protection
1:49 Belly Fat, smoking and blood pressure
2:51 T cell immunity
4:25 Ignoring exercise is a problem
5:11 Skinny but Metabolic Obesity
6:26 Smoking linked with lower antibodies
6:57 Elevated blood pressure associated with lower antibodies
7:54 Physical inactivity is a epidemic
9:45 Sleep and metabolic health
10:39 Lifestyle and V Effectiveness is not new
12:32 Lifestyle tips to improve blood pressure
14:10 Smokers have lower antibodies
15:37 Effectiveness has dropped from 91% to 66%

 

Direct download: Belly_Fat_VE.mp3
Category:general -- posted at: 11:45am PDT

A new study finds breath work practices favorably change brain chemistry mirroring what’s seen in experienced meditators. We review the details and discuss practical ways to incorporate breath work into your life.

 

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Time Stamps

 

0:30 Scientists say breath holds change brain

1:38 Anxiety is top risk for death

2:54 Wim Hof study

3:26 Breath work podcast with Josh Trent

3:43 How breath holds change the brain

5:42 Insight meditation timer

6:36 Breath work podcast with Patrick McKeown

7:03 James Nestor, author of Breathe

7:53 Breathing and brain states

9:42 L-Theanine and the brain

10:34 Right brain activation with breath holds

11:32 Default Mode Network and the brain, Lew Lim and the

12:11 Sleep apnea VS breath holds

13:24 Breath work practice session

Direct download: Breath_work_podcast.mp3
Category:general -- posted at: 4:23pm PDT

Fitness icon Bill Phillips nearly dies from COVID-19. We discuss blood viscosity, hormones and steroid/SARMs as it relates to heart health and risk of severe disease from this particular virus. 


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Time Stamps

0:00 Intro
0:31 Bill Phillips ravaged after C*19
2:17 Mike Shultz, a similar story of HRT user who got hit hard
3:30 Blood Viscosity
4:37 Bill Phillips now after the infection
6:04 Bill admits to steroid use
8:27 Mike's personal steroid use
9:42 How anabolics, SARMs and HRT impact blood work, risk of heart disease

Direct download: Bill_Phillips.mp3
Category:general -- posted at: 12:05pm PDT

Actress Melissa Joan Hart caught The Rona and blames other Americans and her kid's school for her illness. Lets review her recent publicly shared food pictures and discuss the science of insulin resistance as it relates to immune health.

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Time Stamps

0:00 Intro
0:31 Hyperglycemia and risk of illness
1:30 Melissa Joan Hart video
2:00 a look at Melissa's diet
5:00 Blood sugar and Immune Health

Direct download: Melissa_Joan_Hart.mp3
Category:general -- posted at: 8:58am PDT

We review science that shows how exercise can reverse aging by keeping your immune system young, preventing immunosenescence and the process of inflammaging.

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Time Stamps

0:41 Immunosenescence

1:14 Exercise and Immunosenescence

2:14 The senescence-associated secretory phenotype (SASP)

2:25 Thymic Involution and your T cells

2:51 Exercise reverse age related declines in immune function 

3:00 How Exercise Impacts Immune Health 

3:23 More Exercise is not alway better 

4:00 inflammaging: what is it?

4:50 Thymic Involution deep dive

5:40 Exercise and T cells 

6:15 Exercise and Vaccine Responses

9:00 Sleep and Aging 

13:00 Exercise and Immunity Details 

14:30 DHEA, Metformin and Growth Hormone 

15:45 Blood work you need

17:30 Immune System in athletes 

0:00 Intro to exercise as a tool to impact aging 

 

 

Direct download: How_Exercise_Slows_Aging_via_the_immune_system__.mp3
Category:general -- posted at: 9:33am PDT

I misspoke in yesterday’s podcast when saying there’s been, “126 cumulative COVID-19 deaths in children.”

There’s actually been 378 cumulative deaths in children, as of August 12, 2021 in the USA. Very sorry about that.

This brings the case death rate down to 0.01%. (And 0% in some states as not every state has recorded a C*19 death in a child yet.)

The estimated number of children under the age of 19 in the USA is estimated to be around ~ 75,000,000.

Interestingly, during this same time period over 540,918 children have died from other causes. (As of August 12th, 2021.)

So COVID-19 represents 0.07% of all childhood deaths.

Sorry for the confusion.

Here's a link to the podcast and data source: https://bit.ly/3k4QxGO

 

Direct download: kids_and_C_19_mixdown.mp3
Category:general -- posted at: 9:13am PDT

Let's review the published data about how COVID-19 is impacting children and which underlying health conditions in kids are linked with greater disease severity and death.

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Direct download: Data_on_kids.mp3
Category:general -- posted at: 3:21pm PDT

Fasting and calorie restriction are not the only tools that support longevity. Harvard researchers make the case that exercise is the ultimate tool to support longevity and healthy aging.

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Time Stamps

0:00 Intro
0:51 Exercise impacts aging
1:55 9 Hallmarks of Aging
2:36 Genome instability
3:27 Epigenetic /Biologic age testing
4:00 Mitochondrial Dysfunction and exercise
6:00 Exercise and Aging Specifics
8:14 Sleep Loss and Aging
10:00 Exercise May be Better Than Fasting for Aging
11:21 Exercise and aging of the heart
11:45 How much exercise do you need
12:34 Muscle Loss with Age
15:43 Exercise and the brain
18:06 Exercise and Nutrient Sensing
20:01 Exercise, mTOR and AMPK

Direct download: Exercise_and_Longevity_.mp3
Category:general -- posted at: 1:06pm PDT

Let’s review the exact tests you should run to see if you’ve been exposed and/or how your immune system has responded to immunizations. If we're serious about protecting others, we should know the answers to these questions. 

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Antibody VS T Cell Immunity Deep Dive: https://bit.ly/3tRbuYM

Direct download: Got_Antibodies.mp3
Category:general -- posted at: 1:51pm PDT

A new study involving over 100,000 subjects finds exercise and physical activity decreases risk of infectivity, severity and mortality from COVID-19.

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Direct download: Exercise_saves_lives_100K_subjects.mp3
Category:general -- posted at: 9:01am PDT

Researchers in Denmark discovered that fasting impacts key chemicals in the brain differently for lean and obese subjects.


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More about today's show:

After a 24-hour fast, serotonin was increased in appetite regulatory regions in lean but not obese subjects.

Researchers did further analysis and found that fasting-related shifts in insulin and fatty acids were responsible for much of this shift in brain chemicals in the lean subjects.

Here are a few key takeaways from this video:

-Serotonin plays an important role in appetite signaling
-Eating earlier in the day may support higher levels of serotonin and thus better appetite control
-Obese individuals may need to pair exercise with their fasting regimes to gain the most benefit

Direct download: Fasting_Brain_Chemistry.mp3
Category:general -- posted at: 8:48am PDT

Meg Kilcup, PharmD is a pharmacist who was involved in Health Care research but left the industry after growing frustrated that nutrition and lifestyle change were not part of the conversation in a major Seattle health care center.


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Link to video and show notes: https://bit.ly/3Co4JmK

Connect with Meg: https://www.instagram.com/awholehealthlife

Key Time Stamps


0:00 Intro
05:00 Meg found that most patients were not getting better with pharmaceuticals. Lifestyle was never considered.
06:45 On a patient level and system level, getting to the root of the problem was the answer, but it wasn’t happening.
08:30 Western medicine helps many people and kills many people.
09:44 Health is created by the choices we make every day, not healthcare.
12:00 Most people are eating synthetic chemicals for food.
12:45 You can wreck your gut when you eat synthetic foods, instead of natural food. This, in turn, can disrupt your mood, emotions, your hormones and more.
13:25 Doctors have a quality incentive.
14:20 Polypharmacy is a risk factor for disease severity.
16:50 Anxiety can come from many sources: food, hormones, gut health, heavy metal toxicity, poor sleep or a stressful life situation.
19:00 Anti-depressant drugs can increase risk of suicide.
20:00 Increased estrogen from birth control pills can cause hyperpermeability in the intestinal lining.
20:20 Antibiotics wipes out both the pathogenic and the commensal bacteria in your gut.
21:30 PPIs can increase risk of stomach cancer.
24:34 To make an anti-biotic more effective, and reduce antibiotic-resistant bacteria, you can take a probiotic and saccharomyces boulardii probiotic yeast, 4 hours outside of the dosage window.
26:27 Sugar feeds the bad bacteria.
28:37 You can stop taking antibiotics when your symptoms are gone, depending upon the situation.
29:39 There are 47 million antibiotic prescriptions each year.
36:00 Medical journals can be biased. The data can be manipulated before it is published and when it is reported on the news.
44:25 Natural supplements can be as effective and as dangerous, if used incorrectly, as drugs.
57:20 Meg’s morning routine.

Direct download: Meg_Kilcup_PharmD.mp3
Category:general -- posted at: 10:51am PDT

Scientists discover how resistance exercise triggers muscle tissue to signal fat cells to release stored energy (fat). We discuss these details and new research about how muscle mass and muscle quality are linked with improved metabolic flexibility.

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Link to show notes and research: https://bit.ly/3BWrn5c


Time Stamps:

01:31 Marbled unhealthy muscle (Myosteatosis) is characteristic of insulin resistance.
03:12 There is a strong correlation between metabolic health and the degree of muscle fatness.
05:35 Obese study subjects had significantly higher levels of poor-quality muscle, which was independently associated with an increased risk of metabolic syndrome.
05:50 Muscle Fatness/Obesity/Bone Loss is osteosarcopenic obesity.
09:30 Lifting to failure means that you cannot do another.
10:44 With intense exercise, muscle was able to signal white adipose tissue via an extra-cellular vesical, causing increased sensitization to catecholamine stimulation of lipolysis.
11:48 Lipolysis is the release of energy.
12:30 The more muscle you have, the higher your resting metabolic rate.
12:55 Pushing your muscles to failure can directly enhance your fat cell’s ability to release stored energy.
13:00 Fat oxidation occurs within the mitochondria within muscle tissue and liver.
13:30 Many fat lipids are recycled. This recycling declines as you become more insulin resistant.
14:37 Healthy skeletal muscle contributes to whole body glucose metabolism, leptin levels and insulin sensitivity.

Direct download: Muscle_Burns_Fat_Directly.mp3
Category:general -- posted at: 7:37am PDT

Let’s review the long known law of declining virulence which describes how viruses and parasites evolve to become less virulent over time as they infect more hosts.

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Direct download: law_of_declining_virulence_v2.mp3
Category:general -- posted at: 8:03am PDT

Dr. Ben Lynch discusses more about histamine, gut health and why gallbladder issues are so common and tips to optimize. We also look at gene testing and why considering clusters of interrelated genes and their associated networks instead of myopically focusing on one good or bad gene variant is much more useful for determining your health weaknesses and strengths.

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Link to Books and Full Notes: https://bit.ly/3B8reeE


Key Takeaways:

06:23 Genetic testing identifies a potential susceptibility to health and mental health complications. It is one of many tools.
06:50 Dirty Genes book is full of quizzes which identifies genetic issues without doing genetic testing.
07:45 Lifestyle habits are passed down through generations, so issues may not be caused by genes.
08:35 Less than 5% of cancers are heritable. Only 1% of Parkinson’s is genetic.
09:25 Conventional medicine using pharmacological interventions are by force. Naturopathic and functional medicine is nurture and restorative, with an appreciation for the biochemical network.
10:50 Look at genes in a wholistic way. There are about 18,000 genes in our bodies.
12:10 A single variant is minuscule compared to the other 18,000 genes communicating. And there are many other variables that make studying a single variant complicated. For example, is the study subject sleeping in a hot or cold room, mouth breathing, has a sleep partner snoring, and loaded with stress? It appears as though epigenetics overrides the majority of other provocations.
13:40 You must look at the research with a wholistic view. Look at many studies.
14:35 You do not need genetic testing. Listen to how your body is feeling and give those areas in need more love, attention, and protection.
16:12 Some genes are highly influenced by epigenetics and others are not. Sometimes is it a matter of workload for the gene.
18:00 If you have the MTHFR variant, you are less likely to die from malaria. You may have a reduced ability to methylate folate, but methylfolate can be found in leafy green vegetables and animal livers.
20:40 At some point, mutated genes helped your ancestors survive. Our genes are adapting to our new environment, and we are passing this on to our kids.
23:20 Dr. Lynch had to choose 7 genes out of 18,000 for the book. He chose MTHFR because it effects the entire genome. Two glutathione genes were chosen because oxidative stress effects the entire genome.
24:00 CMT and MAOA were chosen for their impact upon brain function.
24:30 DAO works on histamine metabolism in the gut, which can cause leaky gut.
25:00 PEMT: Solid cell membranes create cell membranes and create storage for histamine and your neurotransmitters. This phosphatidyl choline synthesizing gene highly polymorphic.
26:45 Nitric oxide is important for emergent heart issues.
26:50 By focusing on supporting these 7 genes, you are positively influencing all of your genes.
28:45 Phosphatidyl choline keeps your bile from being thick and sludgy. You need 10 parts phosphatidyl choline to one part cholesterol to have your bile flow.
30:23 If you are an obese woman in your 40s and still fertile, you will struggle with a gallbladder issue, especially if you have a PEMT variant. The primary stone in the gallbladder is formed from cholesterol. It stems from fatty liver.
32:44 The phosphatidyl choline supplement is used to improve bile flow, but since it is a lipid, it cannot be fully absorbed to improve bile flow. With PEMT variant, reduce consumption of fats and reduce the workload on that gene.
33:45 Visceral manipulation is a near instant fix for bile flow. It is massage to compress your liver. You will have an amazing bowel movement. Support with herbs that stimulate bile flow and production, like glycine, taurine, bitter herbs, ginger, and artichoke. Then supplement with phosphatidyl choline.
36:00 There is data about bile acids and dysfunctional bile acid signatures in the brain and heart.
36:50 Bile has antimicrobial properties. Taking ox bile at meals to help with fat metabolization. Ox bile taken between meals gets into your small intestine to kill off overgrowth bacteria. Maybe take it with a little charcoal. Bacteria release gasses and compounds that cause issue when they die and break open. Binding these is important.
38:28 Acid reflux is bile coming through a leaky pyloric sphincter.
39:10 The StrateGene test for neurotransmitters looks at the reduction, transport, binding to the receptor and the synthesis/metabolism of key neurotransmitters.
41:20 Pesticides slow the HTR1B gene. They bind to the serotonin receptor.
42:00 The metabolism of neurotransmitters can be fast, typical or slow. Many medications target the reuptake of neurotransmitters to keep it in the brain, rather than have it reabsorbed.
43:00 Many of us who take SSRIs get no effect because they have no or too little serotonin in the brain for the medication to work with.
43:30 5-HTP is a primary precursor to serotonin. The DEC gene converts 5-HTP to serotonin, uses vitamin B-6.
48:20 Sleep is associated with serotonin. Serotonin is converted to your melatonin. Taking supplemental melatonin may mean that serotonin is still in your brain, producing a “wired and tired” feeling.
50:55 Adderall and Ritalin are addictive amphetamines. Amphetamines block the reuptake of dopamine. Harm can be done with higher doses of amphetamines when we already have a slow ability to remove dopamine from the brain.
53:50 Medications can be useful as an intermittent intervention. Many times, non-pharmaceutical interventions can be used strategically with genetic testing.
55:05 Ritalin is toxic to the brain because it keeps so much dopamine in the brain, making dopamine quinone. Three toxic compounds are produced when you break down dopamine.
58:40 We think that Parkinson’s is a low dopamine state, so patients are prescribed L-dopa. L-dopa may have been the reason their brain was toxic to begin with from a messed up MTHFR.
59:15 Supplementing with dopamine hastens the destruction of the Parkinson’s brain. Parkinson’s is a damaged state due to a pro-oxidative environment in the brain, possibly due to more elevated dopamine or a trapping of some of the toxic metabolites of dopamine in the brain.
01:01:17 Quinones are highly reactive and hard to calm and neutralize. Glutathione does not neutralize a reactive quinone. PQQ is helpful. Carnosine is also helpful and rapidly metabolized by carnosinase and converted into histamine and histidine. N-acetyl carnosine keeps carnosine in circulation longer. It is protective of the brain and is also used in eye drops for cataracts.
01:05:20 Eye health/function is an indicator of brain health. Your eyes contain the most mitochondria per density of any organ or body part. Eyes use a lot of oxygen and requires a lot of glutathione and other antioxidants for support.

 

 

Direct download: Gene_Testing_Deep_Dive.mp3
Category:general -- posted at: 2:37pm PDT

New data from 4.8 million hospitalizations finding 94.9% of COVID-19 patients had very common, yet largely preventable, underlying health conditions, including:

-High blood pressure
-Lipid imbalances (commonly caused by insulin resistance)
-Obesity
-Anxiety


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Link to article, video and images: https://bit.ly/3yCeefc

Data from 4.8 million hospital visits debunk the media's constant lie that 'perfectly healthy people are dropping like flies' from the virus.


We review new data collected from 800 US hospitals and 4.8 million medical records from March 2020 to March 2021. The report found that of 540,000 hospitalized for C*19, only 27,000 (5.5%) did not have a chronic health condition.

Over 513,000 of the 540,000 (94.9%) hospitalized for C*19 had at least one chronic health condition; some had as many as 10 or more. (Needless to say a super majority of these conditions reported with high frequencies are created by people's own nutrition, exercise and lifestyle choices: insulin resistance, obesity, mental health issues and more.)

The presence of two or more underlying conditions increases the odds of death nearly 2 fold compared to those with none; 10 or more conditions increases odds of death by nearly 4 fold.

What's even worse--considering the constant media fear mongering--anxiety was found to be the second strongest predictor of death, after obesity. This is after adjusting for age and other variables.

Let’s use this new report to nudge our friends to start making better nutrition, exercise and lifestyle choices.

Direct download: 4.8_million_visits.mp3
Category:general -- posted at: 9:26am PDT

New research suggests blood sugar and insulin surges can impair our circadian clock system, possibly leading to sleep disruptions and more. We then discuss how to avoid the common meal-timing mistake many make when Intermittent Fasting or eating OMAD, adding more evidence to the idea that we should start feeding earlier in the day and start our fast in the early evening.


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Link to show notes: https://bit.ly/36boxux

 

Direct download: glucose_circadian.mp3
Category:general -- posted at: 3:00am PDT

You're hearing a lot about the new Delta Variant. Let's unpack real world science so you can make more informed decisions about the actual lethality and more.


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0:00 Intro
2:24 what is the Delta Variant
3:37 What states have this variant
4:37 Healthy Living is key for prevention, researchers say
9:39 Protein structure equals function
11:04 Hemoglobin A1C and glycosylation
13:00 transmission rates of the delta variant
17:43 Why T cell immunity is so essential
18:45 Data from the UK about lethality of the delta variant

Direct download: Delta_Variant_iTunes.mp3
Category:general -- posted at: 12:17pm PDT

A new study compared Alternate Day Fasting (ADF) to Calorie Restriction (CR), lets unpack what they found and some nuances that the media coverage of the study.

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Direct download: new_fasting_study.mp3
Category:general -- posted at: 12:06pm PDT

Dan Stephenson, CSCS shares amazing nuggets and new science that'll help you get ripped and gain strength this summer.

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Connect with Dan: https://idealstrength.com

Time Stamps: 


07:50 Periodization is the organized structure to your training.
09:15 Your workout program should respect your goals.
11:10 Changing up your modality can accelerate weight loss during the adaptation to that modality.
11:35 The overload principle is where you do more than you did previously: weight, weight lifted over time or weight lifted in a session.
12:40 The gas principle is your general adaptation syndrome, which can lead to maladaptation.
13:10 Four to 6 weeks is time to make changes/variations.
14:10 Hypertrophy is the building of the muscle. Strength is when we ask the muscle to express more force.
17:30 Your recovery is more difficult if you are always redlining during your workout.
20:10 Powerlifting focuses on the glutes. Glutes stabilize the pelvis and helps keep the spine in a neutral position.
21:55 Strong lats and glutes are important for injury prevention and performance.
23:05 Hamstrings help stabilize the pelvis.
27:40 Raw lifting does not use clothing or other accessories that assists with the lift (geared). Raw and geared are separated in competition.
31:00 You can improve your pullup strength with bands.
31:47 Bands accommodate resistance. They are a great way to offload and assist in the bottom portion of the pullup movement.
36:10 Isometrics have been shown to have a pain-relieving effect.
37:00 Yielding isometrics is holding the weight for a period of time before completing the whole rep. Overcoming isometrics is like pushing the bar into an immoveable object.
37:40 Sticking point is where the bar or movement slows down the most, showing where you are weakest in your range of motion.
38:15 Tempo is when you pause where you are weakest or just before where you are weakest.
41:25 A similar movement pattern with fast movement, twitching, can potentiate a lot of type 2 muscle fibers and recruit bigger motor units.
42:05 Failure in lifting is your body giving you feedback and inhibit the muscle from producing force as a way to protect it.
50:20 Bands and suspending weights adds variables that require building of stability. Chains can be used for hypertrophy or strength..
54:00 Increasing the weight as you get stronger, begs you to put more force into the movement.
54:50 Power can be developed with a wide range of intensities.
55:30 Chains for workout are usually ¾ inch or 5/8 inch in 5- or 6-foot chunks. You can layer lighter chains, but you can order online.
59:30 With the Kabuki Kratos flywheel training system, the harder you pull or push (moving the flywheel), the harder it pulls back on you.
01:04:50 Kettlebells are a versatile tool.

Direct download: Dan_fitness_all.mp3
Category:general -- posted at: 2:25pm PDT

Let's dive into new details and about how snacking, overeating and insufficient exercise causes us to gain body fat.

We'll then discuss ways to improve metabolic flexibility to assist in weight loss and blood sugar health improvement. 

Link to science and show notes: https://bit.ly/3xvXO7x

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Direct download: why_you_cant_burn_fat.mp3
Category:general -- posted at: 12:15pm PDT

New research highlights connections with autophagy and a major driver of aging, known as senescence. In today’s show we unpack these details and practical applications as it relates to longevity, fasting and exercise.

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Link to show notes, video and articles discussed: https://bit.ly/3g3Ek4q

Direct download: Autophagy_Aging_and_Senescence_.mp3
Category:general -- posted at: 8:21am PDT

Let’s review new research linking circadian rhythms and age-associated “longevity” pathways of interest, namely the sirtuins, insulin/IGF-1 and mTOR. Let’s review the practical takeaways from this article with a focus on how fasting and caloric restriction ought to be viewed with respect to the circadian clock system.


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Link to video, research and show notes: https://bit.ly/2S7V3KG

Direct download: Circadian_Rhythms_and_Food_.mp3
Category:general -- posted at: 9:16am PDT

Greg Anderson discusses strategies he leans on to support his mental health after spending a decade in the Special Operations/Para-Military community with 14 overseas deployments.

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Video Greg made that cost him his job: https://www.instagram.com/tv/B_0t-MLJlbA/?utm_source=ig_web_copy_link

Connect with Greg:

Greg's jiu jitsu Gym: https://www.theelectricnorth.com

Endless Endeavor Podcast: https://podcasts.apple.com/us/podcast/endless-endeavor-with-greg-anderson/id1520461765

 

0:00 Intro

05:27 Mental Health right now

08:38 Social Isolation and depression

11:07 Blasts and blast overpressures

22:25 Imposter Syndrome

28:52 The video that got Greg Fired

57:00 The state of Censorship

01:01:03 Greg did a 10 day fast to start the year. It kicked his butt.

01:06:25 Once you realize that you can fast for days at a time, you don’t mind missing a meal.

01:08:35 A study of people asthma found that doing 12 days of alternate weekday fasting cut the need for asthma medicines.

01:10:05 To compliment alternate day fasting, athletic people would be advised to eat high protein (keto/carnivore).

01:10:55 Our ancestors ate locally seasonal and we could too.

01:11:42 What your long-ago ancestors ate influences the efficacy of your diet.

01:14:05 Refined carbs and the combination of refined carbs with fat are not found in nature.

01:18:50 Big food wants us to believe in the power of calories rather than carbohydrates. 01:22:40 Masking to prevent viral spread in non-healthcare settings does not have strong support data.

01:24:41 It is healthy to question everything. Who is paying the expert?

01:25:45 Schools have your child for 6 hours a day and exert a great influence.

01:29:14 The majority of people who go through gender reassignment at a young age regret it later.

01:36:06 Cold thermogenesis is a good stress that favorably affects the immune system. It causes mitochondria within your fat cells to enrich.

01:38:29 Try to stay in the cold shower as long as you can. Listen to your body. Make a cold shower part of your routine.

01:52:03 You should be taping your mouth to enhance your sleep. Some experts say that you should tape your mouth during exercise.

02:02:19 In disease, your genetics load the gun, but your environment pulls the trigger. 02:07:46 antibody testing: Use the IGG to SARS COVI2. The decay of the antibodies is different for everyone. Mike had his done through Lab Corp.

02:10:19 Memory T-cell immunity has been shown to last 18 years so far. This immunity can cross over to viruses in the same family.

Direct download: Greg_Anderson_.mp3
Category:Fitness and Nutrition -- posted at: 9:55am PDT

A new study found long-lived plasma cells in the bone marrow of previously infected subjects.

We discuss the details about these critical immune cells and why prioritizing nutrition and health matters even more now.

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Link to Show Notes and Research: https://bit.ly/3wLhXWH

Link to T cell Immunity Deep Dive: https://bit.ly/3tRbuYM

Direct download: Natural_Immunity_.mp3
Category:general -- posted at: 10:47am PDT

New research highlights a critical interplay between autophagy and gut health, specifically with regard to supporting the integrity of the gut barrier.

Today we dive into the details! 

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The Autophagy Enhancer MasterClass: https://courses.highintensityhealth.com

Links to video and show notes: https://bit.ly/2RCnAI2

Direct download: Fasting_Autophagy__Gut_Health_New_Links_with_.mp3
Category:general -- posted at: 4:14pm PDT

We discuss the CDC’s abrupt change in the face mask guidance for folks who’ve been immunized. We’re examining this because it seems to harm the CDC’s credibility. Just days prior to this guidance change, their director, Dr Rochelle Walensky argues that now’s not the time, suggesting that cases are trending in the wrong direction and the data is far from settled. 

We also discuss new autophagy research as it relates to gut health as well as new exciting studies on exercise.

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Direct download: New_Mask_Guidance_.mp3
Category:general -- posted at: 12:24pm PDT

Best selling author Shawn Stevenson discusses how processed foods weaken the body and mind as well as our relationships. It's a fascinating discussion.

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Link to show notes: https://bit.ly/3eF9XAo

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Sleep Smarter: https://amzn.to/3bl6h4V

 

Direct download: Shawn_Stevenson_Audio_.mp3
Category:general -- posted at: 2:57pm PDT

Board certified neurologist Stasha Gominak, MD discusses the reason why you ought to consider mouth tape during sleep. Then we catch up with fitness professional Adrianne Nina to discuss how she used mouth tape, breath holds and other breathing practices to help folks on their fitness journey.

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Conversation with Dr. Gominak: https://youtu.be/74F22bjBmqE

Video chat with Adrianne Nina: https://youtu.be/Dx7eYHBRD4Q

Direct download: Adrianne_and_Stasha_Breathe_.mp3
Category:general -- posted at: 4:41pm PDT

There's a lot of focus on antibodies in the media lately, but T cell immunity might be even more important. In today's show we explore the physiology and science you need to know.


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Link to video and images:

https://highintensityhealth.com/antibody-vs-t-cell-immunity-science-deep-dive

T cell Assay: https://www.t-detect.com

Direct download: T_Cell_Deep_Dive_.mp3
Category:general -- posted at: 12:56pm PDT

Let's breakdown the pros and cons of the four main Intermittent Fasting approaches, from time restricted feeding (TRF), to the 5:2 fasting and Alternate Day Fasting (ADF) and more.

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Direct download: four_types_of_fasting.mp3
Category:general -- posted at: 5:08pm PDT

Sauna therapy has been shown to improve the functioning of the microcirculation, brain, immune system heart and more.

The first 1000 people to click the link will get a free trial of Skillshare's Premium Membership: https://skl.sh/highintensityhealth03211

Link to science: https://bit.ly/3gyJyFN

Direct download: Science_on_a_Saturday_Sauana.mp3
Category:general -- posted at: 10:14am PDT

We unpack several new studies finding regular exercise is linked with reduced chances of hospitalization, ICU time and death from COVID-19 and beyond.

Scientists say Vitamin D supports whole body health! Save on this new Vitamin D3 Liquid w/ MCT Oil by MYOXCIENCE:  Save with code HIH at checkout

 

Link to Video & Notes: https://bit.ly/3gymOpk

 

 

Direct download: Exercise_Saves_Lives_v2.mp3
Category:general -- posted at: 3:06pm PDT

Lets discuss the natural course of immunity and immunologic memory to SARS-CoV-2 and compare and contrast that (natural immunity) to the immunity offered by The Shots currently available.

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Direct download: Antibodies_and_the_jab.mp3
Category:general -- posted at: 11:24am PDT

Researchers say fat issue (adipose) is as a reservoir during viral infections, today we discuss the details. 

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Link to show notes: https://bit.ly/2PMz0YZ

Direct download: fat_and_viral_load.mp3
Category:general -- posted at: 1:49pm PDT

Patrick McKeown is the best selling author of many books on breath. Today he shares tips about female breathing, low back pain, anxiety, insomnia and more.

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Link to show notes, books and more: https://bit.ly/3uwveBG

Direct download: Patrick_audi_only.mp3
Category:general -- posted at: 8:33am PDT

The CDC released the mortality data from 2020, Heart Disease and Cancer claimed 3.7X more lives than Coronavirus and are top risk factors. We discuss this and some new studies on DHEA.

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Link to show notes: https://highintensityhealth.com/cdc-heart-disease-and-cancer-still-leading-caused-of-death-in-2020

Direct download: CDC_2020_leading_causes_of_death_wn.mp3
Category:general -- posted at: 12:58pm PDT

James Nestor, author of Breath reveals why nasal breathing during sleep and exercise is so important.

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Breath is a must read book: https://amzn.to/2KdREFV

Link to Full Interview: https://youtu.be/r9brGbPGJeY

Direct download: Fat_Burns_with_Oxyogen_James.mp3
Category:general -- posted at: 12:07pm PDT

Since sauna bathing has many health benefits, especially for the heart, brain and immune system. In today’s podcast we explore some of the research.

Link to show notes: https://bit.ly/3fywQq8

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Direct download: Sauna_benefits_n.mp3
Category:general -- posted at: 3:39pm PDT

My Mom just turned 64 so we reviewed her most recent blood work focusing on markers of metabolic health (triglycerides, insulin, DHEA, LDL-C, Ferritin, liver enzymes, LDH and more.)

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Link to show notes and video: https://bit.ly/3lTlQox

Direct download: Moms_Blood_Work_.mp3
Category:general -- posted at: 1:04pm PDT

While scientists say C*VID and Obesity is a Pandemic wrapped into an Epidemic, Krispy Kreme offers Americans free donuts and the media reports on it as though it’s a good thing--yikes!

We review why this is scientifically not good and the provide evidence of healthy lifestyle change: https://bit.ly/2P1f4Ro

Get a free 37 page low-carb, keto dessert recipe eBook with any order over $39 at MYOXCIENCE.com using code eBook12 at checkout.

https://bit.ly/keto-ebook-bonus

Direct download: Free_Donuts.mp3
Category:general -- posted at: 2:14pm PDT

Biden's stumble is a reminder about the importance of leg strength as we age.

Various studies have correlated leg strength with healthy ageing, so I thought this ‘current event’ was a good reminder opportunity to discuss and review.

Get a free 37 page low-carb, keto dessert recipe eBook with any order over $39 at MYOXCIENCE.com using code eBook12 at checkout.

Link to show notes: https://bit.ly/3s4T8Di

Direct download: Bidens_Fall_a_Reminder_for_us_all_n.mp3
Category:general -- posted at: 11:39am PDT

Michael Daignault, MD is an ER Physician in LA County. (He knows how serious C*-19 can be.) He’s also a believer that exercise is essential business, because fitness reduces stress and risk factors linked with severe disease! (And the science clearly shows gyms are not a significant source of infections.)

Today’s show is brought to you by MYOXCIENCE: Support your vitamin D & K2 with this Essential Fatty Nutrients! http://bit.ly/38k28ND
Access the bonus recipe eBook using code ebook12 at checkout!

Link to Show Notes and Video: https://bit.ly/3tz4P5v

Direct download: Michael_Daignault_MD.mp3
Category:general -- posted at: 11:04am PDT

Deanna and I dive into the pros and cons of Zone 2 VS Interval training.

Support your Vitamin D & K2 with this updated blend! http://bit.ly/38k28ND​

Access the bonus recipe eBook using code ebook12 at checkout!

Direct download: Deanna_Zonc_2_mixdown2.mp3
Category:general -- posted at: 5:37pm PDT

Support your electrolytes with DIY Electrolyte Bundle: bit.ly/Electrolyte-bundle by MYOXCIENCE
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Connect with Glenn: https://www.saunatimes.com

Key Time Stamps: 


03:09 Glenn practices the Finnish tradition of sauna building.
06:01 Infrared sauna is not a real sauna, according to Glenn.
08:25 The heat up and cool down from sauna are equally important.
11:40 Authentic saunas are most often placed next to lakes in Finland.
15:40 Glenn likes a Friday Happy Hour sauna session to end his work week. Finns traditionally do a Wednesday and a Saturday sauna.
17:52 Sauna can be a vehicle for socialization.
19:40 In Finland, sauna is always done naked, so genders are segregated. In Germany, they sauna naked and co-ed. In the US we sauna in swimsuits and go co-ed.
22:06 Minnesota has a generational tradition of sauna. There are small pockets of generational sauna communities in the US.
24:33 There are mobile saunas. 30:35 Building your own sauna requires W.I.T.: will, information and time. Build at your own pace.
34:07 Building your own is rewarding. Customize and create what you want.
38:00 “Every sauna has its own soul.” The maker of the sauna creates the soul.
46:10 Properly ventilated air, which subtly moves across your body, feels hotter than the ambient temperature. Vents can be added later.
49:22 You can start with a shed or carve it into your garage.

 

Direct download: Glenn_Sauna_times.mp3
Category:general -- posted at: 3:53pm PDT

Two new studies find majority of C*VID-19 hospitalizations and deaths were preventable, Ketogenic diet changes LDL-C in women and Breath Work updates. 

Support your vitamin D3 levels with this updated, new blend! http://bit.ly/38k28ND​

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Link to research mentioned: https://bit.ly/3qtKM6B

Direct download: 575K_Hospitalizations_Preventable.mp3
Category:general -- posted at: 12:15pm PDT

Support your sleep and electrolytes with MYOXCIENCE's Myo Relax this winter!
http://bit.ly/2HgCPOs
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A Pediatrician from Sweden quits amid backlash for reporting actual ICU and death data in kids under 16 years of age in Sweden. (Only 15 children were admitted to the ICU for COVID-related complications in a country of 1.9 million children where schools remained open.) 

Link to show notes: https://bit.ly/3ego6Ev

Direct download: Sweeden_Doctor_Cancelled_.mp3
Category:general -- posted at: 12:34pm PDT

Fat researcher shares new discoveries about fasting, body fat, energy restriction and metabolic rate.

Kickstart your fast with Berberine HCl by MYOXCIENCE. Use code podcast to save 15%

Link to show notes: https://bit.ly/3kIgmMT

-----------------------------------------Show Notes--------------------------------------

 

00:00 Intro

 

04:00 Intermittent fasting is a good solution for stubborn fat. 04:15 Your diet has to work for you for the long run: psychologically, biologically and sociologically.

06:38 Fat is a complex endocrine organ, like the thyroid and adrenal glands.

06:56 Fat produces critical hormones that your body depends upon, like leptin.

07:03 When you lose fat you get lower levels of leptin, which binds with your hypothalamus and your skeletal muscle.

07:55 When skeletal muscle notices less leptin, it burns fewer calories.

09:48 Your genetics may cause you to have to work harder to keep off or lose weight.

10:15 Viruses, age, gender and hormones impact weight. Our fat busting hormones decline with age.

14:00 How your body responds to a food is individual.

14:50 Prolonged overnight fasting prolongs the effects of fat buster, growth hormone.

15:12 With intermittent fasting you get more glucagon, more leptin (so you feel more satiated), and more willpower for making better choices.

16:35 Staying low calorie all day never gives you a sense of satisfaction, leading to increased failure of diet.

19:14 Subcutaneous fat is under your skin. Visceral fat, under the stomach wall, leads to problems with the immune system, diabetes, and heart disease. Brown fat burns calories during cold exposure and beige fat that can turn into brown.

19:42 Visceral fat cells become hypoxic, sending signals of duress and your immune system responds with inflammation, which interferes with insulin signaling.

20:50 Fat releases adiponectin which guides the fat you eat and the fat you release to the right places in your body; to be stores as subcutaneous rather than visceral.

21:22 Sumo wrestlers have subcutaneous fat, not visceral. They exercise 6 – 7 hours per day, releasing higher levels of adiponectin.

22:13 About 2 hours of aerobic activity per day can move your fat to the right areas.

23:30 To see if you have visceral fat, lay on your back and a paunch on your stomach stays there, that is visceral fat. 25:35 Ancestral famines create a thrifty genotype which causes you to hold fat for later.

29:30 Viruses can make animals fat. Some cross into humans. 38:10 You need to be in the right mindset to lose weight.

40:50 HIIT in the evening while fasting busts through weight loss plateaus for Dr. Tara.

41:25 Temptation bundling: Bring something pleasurable into your workout to enhance your ability to create a habit.

43:48 A habit is more reliable than willpower. Reducing the number of decisions you make during the day reduces decision fatigue.

44:16 Successful dieters can get back on their diet the next day. Perfect isn’t the goal.

Direct download: Sylvia_tara_mixdown.mp3
Category:general -- posted at: 11:55am PDT

Today we’re diving into some new studies that show how brief periods of inactivity (so called immobilization studies) worsen blood sugar control.

Link to show notes and research: https://bit.ly/3kkh7eC

Support your sleep and electrolytes with MYOXCIENCE's Myo Relax this winter!

http://bit.ly/2HgCPOs
Use code podcast to save 15%

Direct download: Blood_sugar_and_inactivity_.mp3
Category:general -- posted at: 7:00pm PDT

Here's a link to show notes and resources: https://bit.ly/2OVcgVK

I'm a believer having some basics to prepare for uncertain water and food situations, so hopefully you find these resources helpful! 

 

PETZL Headlamp https://amzn.to/3u65Wux

Jetboil Stove: https://amzn.to/3dhKnBo

Liquid Iodine: https://bit.ly/3k30zYr

SteriPen: https://amzn.to/3bcjz2U

Direct download: Clean_Water_n.mp3
Category:general -- posted at: 12:35pm PDT