High Intensity Health with Mike Mutzel, MS


Scientist and expert advocate in this space Dom D’Agastino articulates just how and why ketones affect the brain.

(The real horse power behind ketosis is its brain-based impacts.)

Though, this shouldn’t come as a surprise; the diet has been used as a last-chance therapy for epilepsy for the better part of 100 years.

 Check out the Show notes: http://highintensityhealth.com/205

Watch the interviewhttps://www.youtube.com/watch?v=XZSf5OC3aOQ&list=PL0ovt_TbvVmYvrI48Tzs1vhe4o2eUn8qU&index=1

He explains how these metabolites that are made by our liver have far-reaching effects on brain function and neurotransmitter metabolism.

Dom also discusses how ketones affect the immune system, cancer-cell metabolism and even heart health.

It’s a fascinating and very detailed discussion. I think you’ll get a lot out of it.

Key Takeaways:

01:38 One of Dr. D’Agostino’s early experiments lead to researchers developing and using ketones as a mitigation countermeasure to prevent oxygen toxicity seizures.
03:17 Nutritional ketosis has a stabilizing effect upon the brain.
03:54 The ketogenic diet and exogenous ketones impact many different mechanisms in synergy. Drugs impact one mechanism.
04:31 The cells of the hippocampus are selectively vulnerable to oxidative stress and energy deprivation, thus make effective study samples.
05:30 Acetyl acetate is neuroprotective, so the ketone esters developed by his lab are high in both acetyl acetate and beta hydroxybutyrate.
08:07 Clinically, the state of nutritional ketosis is defined as an elevation of blood beta hydroxybutyrate 0.5 and above or urine ketones, which measure acetyl acetate, is 15 mg/deciliter or above.
09:54 The more we subject our livers to oxidizing fats for fuel, the greater capacity we will have over time, unless we have a fatty oxidation disorder.
13:34 We may have the ability to robustly increase our capacity to make ketones, as well as break down and use ketones.
15:38 Ketone supplements, especially the ketone esters, have the capacity to be toxic if they are consumed in large quantities.
16:35 Dr. D’Agostino has tested 20 different types of ketones and ketone formulations.
17:22 Ketones have been found to be neuroprotective against high levels of oxygen, reactive oxygen species, glutamate and excitotoxicity.
21:18 The most potent anti-seizure effects found in animal models are from the elevation of both beta hydroxybutyrate and acetyl acetate.
23:52 Independent of their metabolic properties, ketone molecules have potent signaling properties.
29:38 Acetyl acetate does not have an enantiomer. Beta hydroxybutyrate does.
31:36 Exogenous ketones, when consumed as a bolus, can lower blood glucose levels via what appears to be a mechanism that is independent of insulin.
41:40 Ketones mitigate oxidative stress by enhancing mitochondrial energy production and reducing the leaking of electrons through the electron transport chain to molecular oxygen.
44:40 The activity of the enzyme, glutamic acid decarboxylase, is increased when you are in a state of nutritional ketosis and with exogenous ketones.
46:04 Exogenous ketones work through the adenosine A1 receptor. Adenosine is neuroprotective, has many different effects upon the heart and is a potent vasodilator.
46:40 Being in a state of moderate ketosis can augment brain blood flow by up to 30%.
47:18 Your brain stores more creatine when you are in ketosis. Creatine is neuroprotective, even against brain injury.
51:41 Ketosis brings the brain back to a state of balance: energetic balance, redox balance, and probably neurotransmitter balance. In ketosis, the energetic state of a cell can be preserved with less oxygen.
57:39 The ketogenic diet is being found to be effective therapy in a number of diseases..
01:03:32 Being in a state of ketosis, combined with a state of mild calorie restriction, quiets the brain and reduces anxiety behavior (in rodent models).. Parents report that placing their child on a ketogenic style diet improves behavior.
01:06:35 Exogenous ketones can attenuate some of the rebound effect from periodic hypoglycemia, which would activate your sympathetic nervous system.
01:11:26 A ketogenic diet approach can be used to maintain and build muscle.
01:15:10 Your mitochondrial function will be better preserved if you live in a state of or go in and out of a state nutritional ketosis and do intermittent fasting a few times a week.
01:17:02 Exercise is a huge hammer, as big as nutrition, in slowing aging.
01:22:11 The ketogenic diet works for weight loss, in part, through an appetite suppressing effect. Weight loss due to ketone supplementation is from the ketone effects upon brain energy metabolism.
01:31:45 Dr. D’Agostino’s single favorite exercise is the chin-up.
01:32:20 Dr. D’Agostino’s desert island supplement is coffee, which is full of polyphenols.

Direct download: 205_Dom_Eric_Mix.mp3
Category:general -- posted at: 5:09pm PDT

World-renowned human movement expert Darryl Edwards agrees that humans need more exercise and daily movement—but not in the way that many people think. 

Check out the show notes (and watch the video): http://bit.ly/2ygLOvy

He provides us with some examples about how crawling, climbing, jumping, pushing and pulling in different directions are best for long-term health. 

(As much as I love squats and deadlifts, they’re not multi-plane movements.) 

Learn how to exercise and move for health in three dimensions (with friends and family):http://bit.ly/2ygLOvy

In this episode, you’ll learn more details about: 

- How exercising barefoot is better for your body 

- How walking outside is more effective than running inside 

- Simple ways to improve blood sugar regulation by playing in your own backyard 

Check it out and have a chance to try these moves! 

--------------------------------------Key Takeaways----------------------------------

02:10 Your Extraordinary Feet:

03:11 Humans are Movement Generalists:
06:54 Paleo Fitness:
12:12 Start Barefoot Walking:
13:30 You’ll be Lighter on Your Feet:
16:32 Your Feet Spread:
17:51 Training Outside in Natural Weather Conditions:
24:50 A Holistic Practice of Health:
26:13 A State of Mindfulness:
28:35 Low Carbohydrate Diet:
30:24 Darryl was Pre-Diabetic:
33:02 Sleep Quality:
33:42 Darryl’s Desert Island Herb/Nutrient:
34:26 Darryl’s Ideal Morning Routine
36:21 Darryl’s Elevator Pitch


Watch the show notes: http://bit.ly/2ygLOvy

Direct download: 204-Darryl_Edwards_-_Eric_Klein_Mix.mp3
Category:general -- posted at: 1:27pm PDT

Today’s guest, neurologist and sleep specialist Stasha Gominak, MD discusses how vitamin D (from the sun) is needed to improve the stability of gut bacteria, which in turn help synthesize B vitamins necessary to facilitate deep sleep.

Not only that, the repairs that deep sleep offers also appear to be mediated by B vitamins made by gut bacteria, according to Dr. Gominak.

She refers to these bugs as “B vitamin factories.”

Check out the show notes: http://highintensityhealth.com/203

Watch the video interview: https://youtu.be/74F22bjBmqE

(Psst … this isn’t the first time we’ve heard this. James Adams, PhD, reported similar findings from his lab at Arizona State University and discussed them during the Autism Intensive.)

Also, Dr. Gominak reveals another interesting finding about sleep: the brain stem paralyzes us while we’re sleeping (not all at once, but it’s a pulsatile paralysis needed to repair our tissues).

This is why nose breathing while you’re sleeping is super important (a topic we talk about a lot here).

02:29 Hundreds of Dr. Gominak’s patients, children, teenagers and young healthy females, didn’t have REM sleep.
04:42 Sleep apnea, fibromyalgia, chronic fatigue were not recognized in the 1960s and 1970s, because they were not epidemic.
07:21 Vitamin D and the brain stem are major players in deep sleep.
10:03 You must be paralyzed in order to achieve the proper levels of sleep.
14:21 Why would an 8 year old have more than one sleep disorder?
16:02 There has been a major historical shift from living/working/playing outside.
17:07 Once you replace vitamin D, the body slowly changes from a vitamin D deficient body to a B deficient body.
18:08 While bears hibernate, their microbiome consumes the colonic mucus, which makes all of the B vitamins to meet the bear’s metabolic needs during hibernation. Does ours?
22:05 Why Did It Take 2 Years to Become B Deficient?
23:44 Each B vitamin has an intestinal bacterial source and a food source.
26:02 Wanted: Gut Bugs
31:39 You can fix your own bacteria with vitamin D levels above 40 and take B100 or B50 for 3 months.
32:58 The sodium linked multivitamin transport system pumps 3 vitamins, pantothenic acid, alpha lipoic acid and biotin, into our digestive system and our brain.
36:24 Dr. Gominak sees a correlation between autism and vitamin D deficiency.
38:27 The development of sexual dysmorphism and sleep.
42:34 When a child cannot get out of bed in the morning, this is may be the brain demanding that they go back to sleep to get REM.
44:03 A lack of REM sleep cheats a child of their normal development.
47:15 Children and adults normally make small subtle movements and tiny vocalizations, not talking, walking or falling out of bed.
48:27 Taking the Weston A. Price westernization theory to another level.
56:02 Breastfeeding enlarges nasal passages.
57:28 Dr. Gominak believes that vitamin D is trophic to the bacteria that we are supposed to have in our gut.
59:24 Pantothenic acid not only makes acetylcholine, it makes cortisol.
60:11 Acetylcholine is a chemical used by the vagus nerve.
01:07:46 A test result of pantothenic acid levels will parallel magnesium levels. It tells you what is in the blood, but not what is in the stores.
01:09:10 Perhaps we are completely self-healing with REM sleep.
01:12:26 Dr. Gominak’s Morning Routine
01:13:31 The ketogenic diet helps people to live longer. Being ketogenic during REM sleep helps us repair. We were probably designed to go into ketosis for at least 12 hours every night.
01:15:08 A new theory is that the tricarboxylic acid/CREB cycle, which is used when you are using fats as your energy supply, may have a different purpose. It may not be about making ATP.
0101:19:33 Dr. Gominak’s desert island herb, nutrient or supplement: Her choice is vitamin D, even on a desert island.
01:30:35 Dr. Gominak’s Elevator Pitch: We can impact our children, especially children of color. It they don’t go outside, they don’t make enough vitamin D.


Check out the show notes: http://highintensityhealth.com/203


Direct download: 203_Stasha_Eric_Mix_mixdown.mp3
Category:general -- posted at: 4:24pm PDT