Adrenopause: the Decline of DHEA, Low Testosterone and Low Libido

One characteristic of ageing is decreased secretion of the adrenal androgens, DHEA and DHEAS. Termed adrenopause, this condition is problematic people over 40 because DHEA contributes to 50% and 100% of testosterone production in men and post-menopausal women, respectively.

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Link to video, research: https://bit.ly/3N0ZI8s

Time Stamps: 

00:10 Adrenopause is when your adrenals go into a state of decline.

00:30 About 75% of estrogens and androgens come from adrenals in post-menopausal women.

01:00 Adrenopause can appear as low DHEA, low cortisol, low cortisol awakening response, and low libido.

01:40 The adrenal medulla is the innermost portion of the adrenal gland.

01:45 Adrenal glands make epinephrine and norepinephrine.

02:00 The zona reticularis and zona fasciculata are where cortisol and other corticosteroids are released.

02:50 Cortisol should be high in the morning and lower at night.

03:30 Atrophy of portions of the adrenal glands can lead to adrenopause, which is linked with sub-optimal testosterone, poor immunologic responses, aberrant changes in estrogen and vaginal dryness.

05:40 DHEA is metabolized into testosterone, dihydrotestosterone, and estrogen, as well as affect immunologic health, brain tissue and other aspects of physiology.

07:10 Men should test DHEA before considering HRT.

08:10 You can test serum DHEA sulfate, the storage form of DHEA.

08:50 The DUTCH plus complete tests your cortisol awakening response, DHEA, melatonin, estrogen metabolites and progesterone.

09:45 Supplement timing: You may supplement adrenal glandulars and thyroid extracts in the morning and DHEA in the evening.

11:10 General dosing: men – 10 mg/decade of life, women – 2.5mg/decade of life

11:45 Insulin resistance can increase levels of androgens with DHEA supplementation.

12:20 Exposure to morning sunlight and evening sunlight can stimulate your cortisol awakening response.

12:45 The amplitude and intensity of your circadian clock system becomes muted as you age.