Anti-Aging with Rapamycin Over 50: Extending Healthspan w/ Alan Green, MD

Alan Green, MD has been using low-dose rapamycin in his clinical practice for years. We discuss the many potential health benefits and ways this compound can be used as a tool to support healthspan and prevent age-associated diseases. 

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Full Video Interview:  https://bit.ly/3U5S0OQ

Show Notes: 

05:05 Rapamycin stops this deterioration and the development of dementia.
09:47 Pharmaceuticals do not treat end-stage disease. 
11:15 Rapamycin is anti-mTOR. mTOR is involved in all age-related diseases. 
19:35 Evolution’s way to promote new gene variations is to eliminate those with old variations with a short lifespan.
24:40 Ageing is a programed genetic timebomb.
30:50 Slowing mTOR with rapamycin slows ageing.
37:40 Transplant patients do not get the age/health benefits because the dosing of rapamycin is too high. 
40:18 Once a week dosing gives a high level at the beginning of the week to knock out mTOR1 and it was low enough at the end of the week to not interfere with mTOR2. 
41:15 Reducing mTOR1 reduces the activity of the innate immune system. 
42:45 Decreasing the innate immune system is good for stopping chronic inflammation and age-related diseases. 
48:30 A typical dose is 6 mg. It is less for a smaller healthy person. 
50:17 Rapamycin is good for sports performance because it is good for cardiac performance.
54:10 Rapamycin helps maintain strength and quality of muscles.   
55:30 Bodybuilders do not benefit from rapamycin.