Charles Poliquin shares key insights from his four decades of experience training elite athletes and Olympians. 

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Video Interview:  https://youtu.be/1ojJF3Oqanw

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Show Notes

0:00 Intro
4:19 To win the war on fat, you need to win the insulin war.
5:43 Athletes’ Alzheimer’s propensity
6:19 Profound benefits of strength training
7:39 You don’t need carbs. 
8:41 Risk/benefit of peptides like SARMs (Selective Androgen Receptor Modulator)
10:12 The beneficial hormonal influence of doing squats
11:30 DHEA Sulfate, the mother of all androgens
13:50 DHEA for women
15:37 The best anabolic agent is sleep.
17:03 Screen time affects androgens, sleep, weight gain, fitness, and information retention.
21:50 Carbohydrates are not for everyone.
26:20 Managing stress hormones with carbohydrates 
26:40 Meat, wild and domestic, sources of protein
29:06 Meal timing and frequency
31:13 Athletic performance with intermittent fasting and protein/fat consumption 
35:39 Regular blood work is a lie detector.
39:18 Leucine and branch chain amino acids for hypertrophy
42:08 Fish oil for weight loss
44:26 GLA (Gamma-linolenic acid), the healthy Omega 6
45:05 Periodization for burning fat and building muscle
51:23 Mindset and quality over quantity
59:55 Charles’ morning routine
01:04:04 Charles’ favorite nutrients/foods are brain-ready carnitine, curcumin and water buffalo.
01:05:54 Charles’ elevator pitch would be to ban soda and look to the Finns for education reform.

Remnant lipoproteins are being recognized as a better proxy for metabolic health.  

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00:00 Remnant cholesterol is an atherogenic lipid.
01:10 Remnant cholesterol is linked with metabolic dysfunction.
02:10 Remnant cholesterol is a good assessment for non-alcoholic fatty liver disease, diabetes, hypertension, chronic kidney disease, and atherosclerosis diseases. 
02:27 Total cholesterol – HDL – LDL = Remnant Cholesterol.
07:45 Remnant cholesterol levels, with high accuracy, identify metabolic syndrome.
08:50 Remnant cholesterol is a measure of the triglyceride enriched atherogenic lipoprotein. 
10:00 Industrialized seed oils increase the propensity of your atherogenic lipoproteins to become oxidized.
10:50 Women have a higher risk of metabolic syndrome related to remnant cholesterol.
11:50 Older women have significantly higher bodyfat percentage, worse lipid profiles, and worse lipid metabolism then men and younger women.
13:30 Skeletal muscle is important to metabolic health.
14:40 Menopausal bioidentical HRT reduces the risk of a number of diseases.

Record numbers of young women are experiencing early menopause, also known as Premature Ovarian Failure, in their 20s and 30s. Here's the science and details you should know.

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Time Stamps:

00:00 Young women in their 20s and teen girls are going through menopause, premature ovarian insufficiency.

00:37 Nearly 11% of women in North America go through POI.

01:45 POI is a symptom of endocrine disrupting chemical exposure, poor metabolic health, and malnutrition.

03:45 Long-term health issues are caused by low estrogen, progesterone and testosterone.

04:50 Early symptoms

05:30 Indicators: elevated FSH, between 25 IU and 40 IU, and low AMH, below 3.5 picomoles/liter.

06:24 Exposure to certain environmental chemicals compromise reproductive health in women.

10:35 POI is ovarian failure, not early menopause.

Heart disease and cancer have long held the top two causes of death, 2022, 2021 and 2020 were no different, new data suggests. According to the CDC’s recently released 2022 figures, these two health conditions claimed a combined 7 times more lives than COVID-19 in 2022. 

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Link to video review and notes: https://bit.ly/top-cause-of-death-2022

References:

Ahmad, F. B., Cisewski, J. A. & Anderson, R. N. Provisional Mortality Data — United States, 2021. Morbidity Mortal Wkly Rep 71, 597–600 (2022).

Hormonal birth control is linked with altered mood states, including anxiety and depression as well as exaggerated responses to stress.  Sponsored Message:

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Time Stamps: 

00:00 Altered mood states are linked with hormonal birth control.

00:50 IUD’s, other than copper, contain progestins and some have estrogens.

02:00 Elevated depression and stress scores, elevated CRP, and plasma cortisol, are found from hormonal birth control.

04:00 Exaggerated basal neuroendocrine and inflammatory profiles are found with hormonal contraceptive users.

04:20 Hormone users had double the amount of cortisol compared to non-users.

04:40 Synthetic progestins and estrogens are not the same as biologically identical progesterone and estradiol.

07:20 Depression increases your risk from dying from all causes, particularly from cardiovascular disease.

07:45 Neurotransmitter GABA is sensitive to changes in progesterone.

10:50 Neuroactive steroid hormones and the HPAG axis are altered with synthetic hormonal contraceptives.

13:10 History of psychiatric illness increases likelihood of poor mental health while using hormonal contraception.

14:30 Explore birth control alternatives.

Studies Mentioned:

1.Skovlund, C. W., Mørch, L. S., Kessing, L. V. & Lidegaard, Ø. Association of Hormonal Contraception With Depression. Jama Psychiat73, 1154 (2016).

2.Lewis, C. A. et al. Effects of Hormonal Contraceptives on Mood: A Focus on Emotion Recognition and Reactivity, Reward Processing, and Stress Response. Curr Psychiat Rep 21, 115 (2019).

3.Elsayed, M. et al. The potential association between psychiatric symptoms and the use of levonorgestrel intrauterine devices (LNG-IUDs): A systematic review. World J Biological Psychiatry 1–19 (2022) doi:10.1080/15622975.2022.2145354.

4.Raeder, F. et al. Do oral contraceptives modulate the effects of stress induction on one-session exposure efficacy and generalization in women? Psychopharmacology 240, 1075–1089 (2023).

5.Lacasse, J. M., Ismail, N. & Tronson, N. C. Editorial overview: Hormonal contraceptives and the brain: A call for translational research. Front Neuroendocrin 69, 101063 (2023).

6.Martell, S., Marini, C., Kondas, C. A. & Deutch, A. B. Psychological side effects of hormonal contraception: a disconnect between patients and providers. Contracept Reproductive Medicine 8, 9 (2023).

7.Zettermark, S. et al. Population heterogeneity in associations between hormonal contraception and antidepressant use in Sweden: a prospective cohort study applying intersectional multilevel analysis of individual heterogeneity and discriminatory accuracy (MAIHDA). Bmj Open 11, e049553 (2021).