#261: Calorie Deficits and Surpluses, mTOR and Hormones

According to some, weight loss is simply 2nd grade level math.

Burn more energy than you eat, and fat is lost.

Eat more energy than you burn, fat is gained—easy math, right?

In this new show, we review how nutrient sensing enzymes that detect “energy balance” are also influenced by a range of non-nutritive factors, like hormones, inflammation and even oxygen levels.

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Link to show notes: https://highintensityhealth.com/261

Key Takeaways from this chat:

 

07:40: Hormones and energy balance are interconnected

 

08:30 mTOR as a primary energy sensor

 

09:51 How hormones influence & regulate energy switches

 

10:13 The anabolic vs catabolic balance (energy surpluses vs deficits)

 

10:52 How mTOR gets activated

 

11:51 Catabolic states, exercise and AMPK

 

12:40 Insulin, glucagon and malonyl-CoA: the triad that regulates fat synthesis and oxidation

 

14:10 The big picture of energy balance in the context of lifestyle change

 

Link to show notes: https://highintensityhealth.com/261