Vitamin D Deficiency and Impaired Fat Loss: new research and insights

New research suggests Vitamin D influences the structure and function of fat cells and may even impact how much body fat is stored and released to be burned as energy.

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----------------------Show Notes----------------

0:00 Intro
00:26 Vitamin D is sequestered in fat tissue.
00:30 Vitamin D influences your metabolism
00:58 Vitamin D insufficiency causes a dysregulation within your fat cells,
01:30 vitamin D cutaneous synthesis.
02:25 Vitamin D in adipose (fat) tissue affects,
02:40 When you are overweight and obese, your fat cells become necrotic, and they can die.
03:22 The active form of vitamin D
04:30 Vitamin D exerts significant effects on the formation of fat cells (adipogenesis).
05:00 Sufficient levels active metabolites of vitamin D suppress the accelerated adipogenesis, shown in animal and cellular models.
06:00 Vitamin D2 VS vitamin D3
07:00 Vitamin D3 (Cholecalciferol) is acquired from your food or sun exposure. Food sources are fatty fish, dairy, ruminants, the flesh/skin of vertebrae animals, egg yolks and dietary supplements.
08:10 Vitamin D5, sitocalciferol, is derived from an Ayurvedic herb called Rauwolfia serpentina.
09:05 Your liver is responsible for hydroxylating pre-vitamin D into the somewhat active form, calcidiol. This is what is measured in your blood, 25-hydroxy vitamin D.
09:20 Either your fat cells or your kidney further hydroxylates it into 125-dihydroxy vitamin D, calcitriol, is the active form.
09:55 The conversion from 25-hydroxy vitamin D to the 125 dihydroxy vitamin D is down regulated In fat cells, particularly in overweight people.
12:09 Vitamin D activates the vitamin D receptor. Generally, vitamins are cofactors. Vitamin D receptor is found in your fat tissue, kidney, muscle, and bone. When it is activated, it effects your immune system, calcium homeostasis and binding and many inflammatory pathways.
12:55 The vitamin D receptor impacts lipolysis, the release of lipids from your fat cells for energy.
13:18 Your fat tissues store between 35 and 75% of your total body levels of vitamin D.
13:46 People who have diabetes or insulin resistance or are obese, there is less fat cell turnover, which releases vitamin D that was stored in fat cells. So less vitamin D is released to the resto of the body.
14:00 Vitamin d deficiency is 35 to 40% higher in overweight or obese people, or diabetics.
14:30 Vitamin D impacts many functions within the fat cell, including the upregulation of fat cell creation.
15:08 Lipid accumulation decreases with increasing calcitriol (125-dihydroxy vitamin D) dosages.
15:40 Fat cell inflammation is mediated by leptin.
16:40 Chronic activation of immune system cells can trigger inflammation in obesity related pathogenesis in which insulin resistance is involved.
17:03 Nuclear factor-kappa B (NF-kappa B) transcription factor triggers inflammatory cascades within your cells. Vitamin D can inhibit this NF-kappa B activation.
17:30 Overweight or obese individuals have a higher prevalence of vitamin D insufficiency.
18:00 Dosing of supplemental vitamin D should be based upon body fat and health status.
18:23 Vitamin D impacts calcium metabolism. The balance of calcium affects apoptosis, preprogrammed cell death.
19:35 Serum vitamin D levels
20:00 Exercise helps to promote fat cell health and metabolism. It can mobilize fat cell lipids. Flux of fat cells is healthy. Fasting also promotes a healthy churn of your fat tissue.
22:00 With supplemental vitamin D, there are reductions in fasting glucose, hemoglobin A1C, and increases in triglycerides, improving metabolic health.

*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.