Bill Curtis was diagnosed with Parkinson's disease over 17 years ago.
Fasting, exercise and the ketogenic diet has helped to preserve his mental faculties, balance and motor control.
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More details about today's show:
Having studied with ketone pioneer Richard Veech for the past decade, Bill understands the interworkings of how ketones affect the brain and body.
In this chat, he'll share with you the details, including:
- How fasting affects Parkinson's disease symptoms
- A three-tiered approach to help folks with neurocognitive disorders regain function
- The main way ketones are thought to affect the brain and body
01:55 Journalist Bill Curtis has had Parkinson's since 2000. As predicted, he was dramatically affected 10 years later with advanced Parkinson's. Now the only symptom he has is a slight tremor.
04:48 Within about 2 hours of eating carbs, Bill will begin to shake and feel rigid. He doesn't get the full on symptoms he had before.
07:38 Bill was in an exercise program. In an attempt to enhance the effects of the program, he fasted overnight and had nothing for breakfast before the workout. He found it alleviated his profound fatigue.
11:27 Fasting helped with the fatigue, but there were many more symptoms that were not reversed. Bill continued researching.
13:02 Bill exercised fasted every day for a year. He lost weight, but eventually, it stopped working. As you become fit, you make fewer ketones.
15:04 Dr. Veech suggested that Bill try Bulletproof Coffee after the night fast. Nearly all of his symptoms abated at the end of the first hour.
19:36 The military has been experimenting with Dr. Veech's ketone ester for radiation exposure.
22:26 A therapeutic ketogenic diet is one with 80 to 90% of your food as fat. Bill has devised 4 levels of ketosis.
30:33 Within the first 10 days of taking ketone ester, Bill no longer had urinary incontinence.
32:07 There is data that an elevation of uric acid it will delay the onset of Parkinson's. If you have Parkinson's, and your uric acid levels are higher, you decline more slowly.
36:14 BHB allows you to make more dopamine, serotonin, adrenaline, noradrenaline and nitric oxide.
38:00 In advanced Parkinson's neurotransmitters are negatively impacted. With ketosis, you are making serotonin, noradrenaline, adrenaline, dopamine and nitric oxide synthase.
38:52 Every antioxidant has to be recharged with an electron from NADPH, directly or indirectly.
39:50 Beta hydroxybutyrate raises NADPH levels using isocitrate dehydrogenase in the cytoplasm, outside of the mitochondria.
42:24 NADPH levels in the mitochondria does not correlate with NADPH levels in the cytosol. We should measure the cytosolic NADPH.
44:09 NADPH voltage is dependent upon the relative concentrations. More equals more resilience.
48:52 Dismutase does not get its electrons from the battery. It does this by taking 2 molecules of superoxide, oxidizing one and reducing the other.
52:59 You have the ability to use ketones to restore ischemia-reperfusion and turn off inflammation.
54:08 NADPH controls inflammation.
55:04 Dr. Veech found that treating Alzheimer's mouse models with beta hydroxybutyrate kept them from accumulating beta amyloid deposits.
58:03 Bill believes that TBI will respond very well to BHB, as evidenced by people close to him with head injuries.
01:02:41 Bill has created an online course to help people help each other. You need a cook, a coach, a nutritionist and a doctor.
01:04:36 Bill must still take his Parkinson's medications.